Evidence map›Paper›PMID 26823815›Full record

ArticleInternational journal of clinical and experimental pathology2015

Combined detection of preoperative serum CEA, CA19-9 and CA242 improve prognostic prediction of surgically treated colorectal cancer patients.

Jingtao Wang, Xiao Wang, Fudong Yu, Jian Chen, Senlin Zhao, Dongyuan Zhang, Yang Yu, Xisheng Liu, Huamei Tang, Zhihai Peng

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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  17. Experimental and therapeutic medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jingtao WangDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Xiao WangDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Fudong YuDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Jian ChenDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Senlin ZhaoDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Dongyuan ZhangDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Yang YuDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Xisheng LiuDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Huamei TangDepartment of Pathology, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Zhihai PengDepartment of General Surgery, First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Shanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed the prognostic significance of preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 242 (CA242) levels in surgically treated colorectal cancer patients. The relationship of preoperative serum CEA, CA19-9 and CA242 levels with disease characteristics was investigated in 310 patients. Correlation between tumor markers was investigated using Pearson correlation test. Univariate and multivariate survival analyses were used to study the relationship between preoperative tumor markers and prognosis [disease free survival (DFS) and overall survival (OS)]. Kaplan-Meier analysis with log rank test was used to assess the impact of tumor marker levels on survival. Positive rate of preoperative serum CEA, CA19-9 and CA242 were 54.84%, 47.42% and 37.10%, respectively. High preoperative CEA level was associated with tumor size (P = 0.038), T stage (P < 0.001) and AJCC stage (P = 0.002). High preoperative CA19-9 level was associated with tumor AJCC stage (P = 0.023). Preoperative CA242 positively correlated with CEA (P < 0.001) and CA19-9 (P < 0.001). Combining the three markers was of independent prognostic value in CRC (HR = 2.532, 95% CI: 1.400-4.579, P = 0.002 for OS; and HR = 2.366, 95% CI: 1.334-4.196, P = 0.003 for DFS). Combined detection of preoperative serum CEA, CA19-9 and CA242 is of independent prognostic value for management of CRC patients treated surgically.

Indexed as

AdultAgedAged, 80 and overAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCA-19-9 AntigenCarcinoembryonic AntigenColorectal NeoplasmsDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisProportional Hazards ModelsAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCA-19-9 AntigenCA 242 antigenCarcinoembryonic Antigencarbohydrate antigen 19-9carbohydrate antigen 242Carcinoembryonic antigencolorectal cancerprognosis

Identifiers

PMID26823815
PMCPMC4713601
OpenAlexW2407204928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.