ArticleInternational journal of clinical and experimental pathology2015
Differential loss of natural killer cell activity in patients with acute myocardial infarction and stable angina pectoris.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Leukocyte-Mediated Cardiac Repair after Myocardial Infarction in Non-Regenerative vs. Regenerative Systems.Journal of cardiovascular development and disease · 2022Review
- Epithelial-mesenchymal transition-related genes in coronary artery disease.Open medicine (Warsaw, Poland) · 2022Article
- Identification of Potential Diagnostic Biomarkers From Circulating Cells During the Course of Sleep Deprivation-Related Myocardial Infarction Based on Bioinformatics Analyses.Frontiers in cardiovascular medicine · 2022Article
- Systemic immune microenvironment and regulatory network analysis in patients with lung adenocarcinoma.Translational cancer research · 2021Article
- The Role of Natural Killer (NK) Cells in Acute Coronary Syndrome: A Comprehensive Review.Biomolecules · 2020Review
- Collapsing the list of myocardial infarction-related differentially expressed genes into a diagnostic signature.Journal of translational medicine · 2020Article
- (Re) Solving Repair After Myocardial Infarction.Frontiers in pharmacology · 2018Article
- Leukocyte diversity in resolving and nonresolving mechanisms of cardiac remodeling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the activity of natural killer cells through their inhibitory and activating receptors and quantity in peripheral blood mononuclear cells extracted from patients with acute myocardial infarction, stable angina pectoris and the controls.
methods100 patients with myocardial infarction, 100 with stable angina, and 20 healthy volunteers were recruited into the study. 20 randomly chosen people per group were examined for the whole human genome microarray analysis to detect the gene expressions of all 40 inhibitory and activating natural killer cell receptors. Flow cytometry analysis was applied to all 200 patients to measure the quantity of natural killer cells.
resultsIn myocardial infarction group, the mRNA expressions of six inhibitory receptors KIR2DL2, KIR3DL3, CD94, NKG2A, KLRB1, KLRG1, and eight activating receptors KIR2DS3, KIR2DS5, NKp30, NTB-A, CRACC, CD2, CD7 and CD96 were significantly down-regulated (P<0.05) compared with both angina patients and the controls. There was no statistical difference in receptor expressions between angina patients and control group. The quantity of natural killer cells was significantly decreased in both infarction and angina patients compared with normal range (P<0.001).
conclusionsThe significant mRNAs down-regulation of several receptors in myocardial infarction group and reduction in the quantity of natural killer cells in both myocardial infarction and angina patients showed a quantitative loss and dysfunction of natural killer cells in myocardial infarction patients.
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Identifiers
26823790PMC4713576W2411514946What OpenQuestion holds
Registered trials
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