Evidence map›Paper›PMID 26823784›Full record

ArticleInternational journal of clinical and experimental pathology2015

Expression of tumoral FOXP3 in gastric adenocarcinoma is associated with favorable clinicopathological variables and related with Hippo pathway.

Jung-Ho Suh, Kyu Yeoun Won, Gou Young Kim, Go Eun Bae, Sung-Jig Lim, Ji-Youn Sung, Yong-Koo Park, Youn Wha Kim, Juhie Lee

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  10. [Emerging roles of Hippo signaling pathway in gastrointestinal cancers and its molecular mechanisms].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jung-Ho SuhDepartment of Internal Medicine, Graduate School of Medicine, Kyung Hee University Seoul, South Korea.
Kyu Yeoun WonDepartment of Pathology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University Seoul, South Korea.
Gou Young KimDepartment of Pathology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University Seoul, South Korea.
Go Eun BaeDepartment of Pathology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University Seoul, South Korea.
Sung-Jig LimDepartment of Pathology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University Seoul, South Korea.
Ji-Youn SungDepartment of Pathology, Kyung Hee University Hospital, School of Medicine, Kyung Hee University Seoul, South Korea.
Yong-Koo ParkDepartment of Pathology, Kyung Hee University Hospital, School of Medicine, Kyung Hee University Seoul, South Korea.
Youn Wha KimDepartment of Pathology, Kyung Hee University Hospital, School of Medicine, Kyung Hee University Seoul, South Korea.
Juhie LeeDepartment of Pathology, Kyung Hee University Hospital, School of Medicine, Kyung Hee University Seoul, South Korea.
Kyung Hee University Hospital at Gangdong · KRKyung Hee University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FOXP3 is a transcription factor and well-known hallmark of immune suppressive T regulatory cells (Tregs). Recent studies indicate that, in addition to its association with Treg function in the immune system, FOXP3 plays an important role in tumor development. And important tumor suppressor relay between the FOXP3 and Hippo pathways was found in human cancer. Thus, we investigated tumoral FOXP3, infiltrated Tregs count, Lats2, and YAP expression in gastric adenocarcinoma, and the relationships between expression of these three proteins and p53, Ki67, and other clinicopathological variables. We used 118 gastric adenocarcinoma tissues via immunohistochemical analysis, using a tissue microarray, in relation to survival and other clinicopathological factors. We report the several novel observations about the relationship between tumoral FOXP3 and Hippo pathway components in gastric adenocarcinoma. Positive tumoral FOXP3 expression was significantly related with smaller tumor size, tubular tumor type, lower histological grade, lower T stage, lower recurrence rate, less lymphatic invasion, and less neural invasion. Furthermore, patients with positive tumoral FOXP3 experienced significantly better disease-free and overall survival compared to patients with negative tumoral FOXP3. These findings show that tumoral FOXP3 expression is associated with favorable clinicopathological variables in gastric adenocarcinoma. And we report the novel observation of a relationship between tumoral FOXP3 and Hippo pathway components in gastric adenocarcinoma. Tumoral FOXP3 expression, infiltrated Tregs count, and Lats2 expression were all positively correlated with YAP expression. These findings suggest that the Hippo pathway in gastric adenocarcinoma might be influenced by both tumoral FOXP3 and infiltrated Tregs. In conclusion, the loss of FOXP3 expression in cancer cells is thought to contribute to tumorigenesis and progression of gastric adenocarcinoma. The expression of FOXP3 in gastric adenocarcinoma is related with Lats2 and YAP expression of the Hippo pathway.

Indexed as

Signal TransductionAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCell Cycle ProteinsFemaleForkhead Transcription FactorsHippo Signaling PathwayHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedNuclear ProteinsBiomarkers, TumorCell Cycle ProteinsForkhead Transcription FactorsFOXP3 protein, humanLATS2 protein, humanNuclear ProteinsProtein Serine-Threonine KinasesTranscription FactorsTumor Suppressor ProteinsYY1AP1 protein, humanFOXP3Gastric adenocarcinomaLats2YAP

Identifiers

PMID26823784
PMCPMC4713570
OpenAlexW2261131327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.