Evidence map›Paper›PMID 26823774›Full record

ArticleInternational journal of clinical and experimental pathology2015

KIR2DL4 expression rather than its single nucleotide polymorphisms correlates with pre-eclampsia.

Dandan Wang, Yuan Tian, Yanhui Zhao, Lianlian Liu, Xianying Liu, Fuju Wu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. The Role of Killer Ig-like Receptors in Diseases from A to Z.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dandan WangDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.
Yuan TianDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.
Yanhui ZhaoDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.
Lianlian LiuDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.
Xianying LiuDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.
Fuju WuDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.
Second Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the single nucleotide polymorphisms and expression of KIR2DL4 (killer cell immunoglobulin-like receptors) gene in pre-eclampsia patients.

methodsKIR2DL4 gene polymorphisms were detected in 100 patients with pre-eclampsia and 100 healthy pregnant women, respectively, by using PCR-SS. Then, the expression of KIR2DL4 was measured in 5 cases of placentas tissues with pre-eclampsia and normal pregnancies by using qRT-PCR.

resultsCompared with healthy controls, 16 loci of single nucleotide polymorphisms (SNP) were identified in pre-eclampsia patients, including 7 new polymorphisms loci. But, no significant difference was found in genotype distributions and allele frequencies in pre-eclampsia and controls (P>0.05). However, qRT-PCR results showed that KIR2DL4 mRNA in placenta tissues with pre-eclampsia was significantly lower than those with normal pregnancy, and the difference was statistically significant.

conclusionDecreased level of KIR2DL4 rather than its SNP is correlated with the susceptibility of pre-eclampsia.

Indexed as

AdultCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotidePre-EclampsiaPregnancyReceptors, KIR2DL4Reverse Transcriptase Polymerase Chain ReactionYoung AdultKIR2DL4 protein, humanReceptors, KIR2DL4KIR2DL4pre-eclampsiasingle nucleotide polymorphismssusceptibility

Identifiers

PMID26823774
PMCPMC4713560
OpenAlexW2269966649

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.