ArticleInternational journal of clinical and experimental pathology2015
MiR-211 inhibits cell proliferation and invasion of gastric cancer by down-regulating SOX4.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Circular RNA circMTO1 suppressed the progression of renal cell carcinoma progression by sponging miR-211 and miR-204.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Targeting AURKA by microRNA-490-3p suppresses gastric cancer cell growth.Histology and histopathology · 2022Article
- Role and mechanism of miR-211 in human cancer.Journal of Cancer · 2022Review
- Evaluation of circulating microRNAs-211 and 25 as diagnostic biomarkers of colorectal cancer.Molecular biology reports · 2021Article
- Propofol Suppresses Gastric Cancer Progression by Regulating circPDSS1/miR-1324/SOX4 Axis.Cancer management and research · 2021Article
- MiRNA-211 triggers an autophagy-dependent apoptosis in cervical cancer cells: regulation of Bcl-2.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- MiR-596 down regulates SOX4 expression and is a potential novel biomarker for gastric cancer.Translational cancer research · 2020Article
- Identifying critical state of complex diseases by single-sample Kullback-Leibler divergence.BMC genomics · 2020Article
- The Paradoxical Behavior of microRNA-211 in Melanomas and Other Human Cancers.Frontiers in oncology · 2020Review
- Construction and Investigation of a lncRNA-Associated ceRNA Regulatory Network in Cholangiocarcinoma.Frontiers in oncology · 2019Article
- MiRNA-134 suppresses esophageal squamous cell carcinoma progression by targeting FOXM1.International journal of clinical and experimental pathology · 2019Article
- miR-211 inhibits proliferation, invasion and migration of cervical cancer via targeting SPARC.Oncology letters · 2018Article
- ADAR1-mediated regulation of melanoma invasion.Nature communications · 2018Article
- Tumor suppressor miR-211-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma.Experimental and therapeutic medicine · 2018Article
- MicroRNA-211 suppresses prostate cancer proliferation by targeting SPARC.Oncology letters · 2018Article
- Downregulation of tissue miR-338-3p predicts unfavorable prognosis of gastric cancer.Cancer biomarkers : section A of Disease markers · 2017Article
- Basic Transcription Factor 3 Is Required for Proliferation and Epithelial-Mesenchymal Transition via Regulation of FOXM1 and JAK2/STAT3 Signaling in Gastric Cancer.Oncology research · 2017Article
- Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1.Oncology reports · 2017Article
- Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1.Oncology reports · 2017Article
- Propofol Suppresses Esophageal Squamous Cell Carcinoma Cell Migration and Invasion by Down-Regulation of Sex-Determining Region Y-box 4 (SOX4).Medical science monitor : international medical journal of experimental and clinical research · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious studies have shown that the dysregulation of miRNAs are frequently associated with cancer progression. Deregulation of miR-211 has been observed in various types of human cancers. However, its biological function in gastric cancer (GC) is still unknown.
methodsThe expression of miR-211 in GC was detected by using quantitative real-time PCR (qRT-PCR). The miR-211 mimics and inhibitor were designed and transfected into BGC-823 cells. Then, we explore the probable biological function of miR-211 in gastric cancer cell proliferation and invasion in vitro. A luciferase reporter assay and western blot were performed to confirm the target gene of miR-211.
resultsMiR-211 was significantly down-regulated in GC. Over-expression of miR-211 inhibited gastric cancer cell proliferation and invasion in vitro, conversely, down-regulated expression of miR-211 promoted gastric cancer cell proliferation and invasion. In addition, the sex-determining region Y-related high mobility group box 4 (SOX4) is identified as a target of miR-211 in GC cells, and SOX4 expression levels was inversely correlated with miR-211. Furthermore, knockdown of Sox4 inhibited the proliferation and invasion in GC cells.
conclusionmiR-211 could inhibit GC cell proliferation and invasion partially by down-regulating SOX4. MiR-211 might be a potential therapeutic target for GC treatment in the future.
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Identifiers
26823713PMC4713499What OpenQuestion holds
Registered trials
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