ArticleInternational journal of dentistry2015
Association between IFN-γ +874A/T and IFN-γR1 (-611A/G, +189T/G, and +95C/T) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population.
Article in International journal of dentistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis.Frontiers in immunology · 2021Pooled it
- Is there an association between IFN-γ +874A/T polymorphism and periodontitis susceptibility?: A meta-analysis.Medicine · 2017Pooled it
- The influence of genetic variants of IL-6 (-174 G/C) and INFγ (+ 874 A/T) and their impact on anemic Sudanese children with kidney failure.BMC research notes · 2025Article
- Interferon-Gamma (IFNg) +874A/T Polymorphism Does Not Significantly Affect the Severity of Periodontitis.European journal of dentistry · 2022Article
- Association of IFN-γ polymorphisms with ankylosing spondylitis risk.Journal of cellular and molecular medicine · 2020Article
- Micheliolide alleviates ankylosing spondylitis (AS) by suppressing the activation of the NLRP3 inflammasome and maintaining the balance of Th1/Th2 via regulating the NF-κB signaling pathway.Annals of translational medicine · 2020Article
- Interferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- CCR5, MCP-1 and VDR Gene Polymorphisms Are Associated with the Susceptibility to HBV Infection.Indian journal of clinical biochemistry : IJCB · 2019Article
- Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview.BMC oral health · 2019Review
- Are There Any Common Genetic Risk Markers for Rheumatoid Arthritis and Periodontal Diseases? A Case-Control Study.Mediators of inflammation · 2019Article
- A gene variation of Interferon Gamma Receptor-I promoter (rs1327474A>G) and chronic hepatitis C virus infection.Gastroenterology and hepatology from bed to bench · 2019Article
- IFN-γR2 is strongly expressed on endothelial cells of gingival tissues from patients with chronic periodontitis.Journal of applied oral science : revista FOB · 2018Article
- Effect of Interferon-γ Polymorphisms on Ankylosing Spondylitis: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population.Head & face medicine · 2017Article
- Analysis of interleukin-10 gene polymorphisms in patients with chronic periodontitis and healthy controls.Dental research journalArticle
- Immunoexpression of interferon-gamma in the interdental gingiva of chronic periodontitis patients with interferon-gamma (+874A/T) rs62559044 polymorphism.Journal of oral biology and craniofacial researchArticle
- Association of macrophage migration inhibitory factor gene polymorphisms with chronic periodontitis in a South Eastern Iranian population.Dental research journalArticle
- Association of TGF-β1 with periodontitis patients in north Indian population.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Interferon gamma (IFN-γ) is an immune regulatory cytokine that acts through its receptor and plays important role in progression of inflammatory disease such as chronic periodontitis (CP). The purpose of this study was to determine the differences in the distribution of IFN-γ (+874A/T) and IFN-γR1 (-611A/G, +189T/G, and +95C/T) gene polymorphisms among CP and healthy individuals and to investigate relationships between these polymorphisms and susceptibility to CP. Materials and Methods. 310 individuals were enrolled in the study including 210 CP patients and 100 healthy controls. Single nucleotide polymorphisms at IFN-γ (+874A/T) and IFN-γR1 (-611A/G, +189T/G, and +95C/T) were analyzed by ARMS-PCR and PCR-RFLP methods. Results. The significant difference was found in genotype and allele frequency of IFN-γ (+874A/T) gene polymorphism in chronic periodontitis patients and healthy controls. The distribution of genotypes and allele frequencies for IFN-γR1 (-611A/G, +189T/G, and +95C/T) were similar among the groups and no differences in the frequencies of alleles or genotypes of IFN-γR1 genetic polymorphisms variants between case and control groups were detected. Conclusion. The finding of this study showed that IFN-γ +874A/T gene polymorphism may affect susceptibility to CP, whereas IFN-γR1 genetic polymorphisms at -611A/G, +189T/G, and +95C/T were not associated with this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.