ArticleJournal of neurophysiology2016
Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Mediation of mammalian olfactory response by presence of odor-evoked potassium current.Frontiers in allergy · 2024Article
- Experimental and theoretical probe on mechano- and chemosensory integration in the insect antennal lobe.Frontiers in physiology · 2022Article
- Intermediate conductance CaFrontiers in insect science · 2022Article
- Article
- Odor processing in the cockroach antennal lobe-the network components.Cell and tissue research · 2021Review
- In-situ recording of ionic currents in projection neurons and Kenyon cells in the olfactory pathway of the honeybee.PloS one · 2018Article
- Transient voltage-activated KJournal of neurophysiology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca(2+)-activated potassium currents [IK(Ca)] are an important link between the intracellular signaling system and the membrane potential, which shapes intrinsic electrophysiological properties. To better understand the ionic mechanisms that mediate intrinsic firing properties of olfactory uniglomerular projection neurons (uPNs), we used whole cell patch-clamp recordings in an intact adult brain preparation of the male cockroach Periplaneta americana to analyze IK(Ca) In the insect brain, uPNs form the principal pathway from the antennal lobe to the protocerebrum, where centers for multimodal sensory processing and learning are located. In uPNs the activation of IK(Ca) was clearly voltage and Ca(2+) dependent. Thus under physiological conditions IK(Ca) is strongly dependent on Ca(2+) influx kinetics and on the membrane potential. The biophysical characterization suggests that IK(Ca) is generated by big-conductance (BK) channels. A small-conductance (SK) channel-generated current could not be detected. IK(Ca) was sensitive to charybdotoxin (CTX) and iberiotoxin (IbTX) but not to apamin. The functional role of IK(Ca) was analyzed in occlusion experiments under current clamp, in which portions of IK(Ca) were blocked by CTX or IbTX. Blockade of IK(Ca) showed that IK(Ca) contributes significantly to intrinsic electrophysiological properties such as the action potential waveform and membrane excitability.
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