ArticleJournal of neurophysiology2016
Neuronal coupling by endogenous electric fields: cable theory and applications to coincidence detector neurons in the auditory brain stem.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Extracellular stimulation and ephaptic coupling of neurons in a fully coupled finite element-based Extracellular-Membrane-Intracellular (EMI) model.Frontiers in computational neuroscience · 2026Article
- Article
- Computing with electromagnetic fields rather than binary digits: a route towards artificial general intelligence and conscious AI.Frontiers in systems neuroscience · 2025Article
- Thermal effects and ephaptic entrainment in Hodgkin-Huxley model.Scientific reports · 2024Article
- Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Electrophysiological damage to neuronal membrane alters ephaptic entrainment.Scientific reports · 2023Article
- Modelling the effect of ephaptic coupling on spike propagation in peripheral nerve fibres.Biological cybernetics · 2022Article
- Ephaptic entrainment in hybrid neuronal model.Scientific reports · 2022Article
- An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.PLoS computational biology · 2021Article
- Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays.PLoS computational biology · 2021Article
- Modelling the effects of ephaptic coupling on selectivity and response patterns during artificial stimulation of peripheral nerves.PLoS computational biology · 2020Article
- A mathematical model of ephaptic interactions in neuronal fiber pathways: Could there be more than transmission along the tracts?Network neuroscience (Cambridge, Mass.) · 2020Article
- Finite Element Simulation of Ionic Electrodiffusion in Cellular Geometries.Frontiers in neuroinformatics · 2020Article
- Action potential propagation and synchronisation in myelinated axons.PLoS computational biology · 2019Article
- EFrontiers in neuroinformatics · 2019Article
- Article
- Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat.Journal of neurophysiology · 2018Article
- Multimodal Modeling of Neural Network Activity: Computing LFP, ECoG, EEG, and MEG Signals With LFPy 2.0.Frontiers in neuroinformatics · 2018Article
- Senomic view of the cell: SenomeCommunicative & integrative biology · 2018Review
- Signatures of Somatic Inhibition and Dendritic Excitation in Auditory Brainstem Field Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ongoing activity of neurons generates a spatially and time-varying field of extracellular voltage (Ve). This Ve field reflects population-level neural activity, but does it modulate neural dynamics and the function of neural circuits? We provide a cable theory framework to study how a bundle of model neurons generates Ve and how this Ve feeds back and influences membrane potential (Vm). We find that these "ephaptic interactions" are small but not negligible. The model neural population can generate Ve with millivolt-scale amplitude, and this Ve perturbs the Vm of "nearby" cables and effectively increases their electrotonic length. After using passive cable theory to systematically study ephaptic coupling, we explore a test case: the medial superior olive (MSO) in the auditory brain stem. The MSO is a possible locus of ephaptic interactions: sounds evoke large (millivolt scale)Vein vivo in this nucleus. The Ve response is thought to be generated by MSO neurons that perform a known neuronal computation with submillisecond temporal precision (coincidence detection to encode sound source location). Using a biophysically based model of MSO neurons, we find millivolt-scale ephaptic interactions consistent with the passive cable theory results. These subtle membrane potential perturbations induce changes in spike initiation threshold, spike time synchrony, and time difference sensitivity. These results suggest that ephaptic coupling may influence MSO function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.