ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Pulse pressure-dependent cerebrovascular eNOS regulation in mice.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- The impact of age and sex on cerebral and large artery stiffness and the response to pulse pressure.American journal of physiology. Heart and circulatory physiology · 2025Article
- Pulse Pressure Impairs Cognition via White Matter Disruption.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Non-invasive real-time pulsed Doppler assessment of blood flow in mouse ophthalmic artery.Cell reports methods · 2025Article
- Impact of arterial stiffness on cerebrovascular function: a review of evidence from humans and preclincal models.American journal of physiology. Heart and circulatory physiology · 2024Review
- Effects of high-intensity interval training in a cold environment on arterial stiffness and cerebral hemodynamics in sedentary Chinese college female students post-COVID-19.Frontiers in neurology · 2024Article
- Cerebral pulsatility in relation with various imaging markers of cerebral small vessel disease: a longitudinal community-based study.Therapeutic advances in neurological disorders · 2024Article
- High pulse pressure impairs cerebral artery endothelial function in young, but not old, mice.Experimental gerontology · 2023Article
- Pyridoxamine treatment ameliorates large artery stiffening and cerebral artery endothelial dysfunction in old mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- The role of nitric oxide in flow-induced and myogenic responses in 1A, 2A, and 3A branches of the porcine middle cerebral artery.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Sex Differences in Large Artery Stiffness: Implications for Cerebrovascular Dysfunction and Alzheimer's Disease.Frontiers in aging · 2021Article
- High-but not moderate-intensity exercise acutely attenuates hypercapnia-induced vasodilation of the internal carotid artery in young men.European journal of applied physiology · 2021Article
- Carotid pulse pressure and intima media thickness are independently associated with cerebral hemodynamic pulsatility in community-living older adults.Journal of human hypertension · 2020Article
- Pathological Continuum From the Rise in Pulse Pressure to Impaired Neurovascular Coupling and Cognitive Decline.American journal of hypertension · 2020Review
- Non-pulsatile blood flow is associated with enhanced cerebrovascular carbon dioxide reactivity and an attenuated relationship between cerebral blood flow and regional brain oxygenation.Critical care (London, England) · 2019Article
- Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes.American journal of physiology. Endocrinology and metabolism · 2019Article
- Systolic hypertension-induced neurovascular unit disruption magnifies vascular cognitive impairment in middle-age atherosclerotic LDLrGeroScience · 2019Article
- Matched increases in cerebral artery shear stress, irrespective of stimulus, induce similar changes in extra-cranial arterial diameter in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Cerebral and skeletal muscle feed artery vasoconstrictor responses in a mouse model with greater large elastic artery stiffness.Experimental physiology · 2019Article
- Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline.American journal of physiology. Heart and circulatory physiology · 2018Review
- Brain tissue pulsatility is related to clinical features of Parkinson's disease.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial blood pressure is oscillatory; whether pulse pressure (PP) regulates cerebral artery myogenic tone (MT) and endothelial function is currently unknown. To test the impact of PP on MT and dilation to flow (FMD) or to acetylcholine (Ach), isolated pressurized mouse posterior cerebral arteries were subjected to either static pressure (SP) or a physiological PP (amplitude: 30 mm Hg; frequency: 550 bpm). Under PP, MT was significantly higher than in SP conditions ( p < 0.05) and was not affected by eNOS inhibition. In contrast, under SP, eNOS inhibition increased ( p < 0.05) MT to levels observed under PP, suggesting that PP may inhibit eNOS. At a shear stress of 20 dyn/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.