ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
Aging alters the dampening of pulsatile blood flow in cerebral arteries.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 128 citations in OpenAlex.
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- Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness.Experimental physiology · 2026Article
- Ultrafast fMRI Detects Age-Related Changes in Harmonics of Cardiac Pulsations in the Brain at 7 T.Magnetic resonance in medicine · 2026Article
- Regional Cerebrospinal Fluid Motility as a Key Determinant of Soluble Amyloid-β Levels and Kinetics.Research square · 2026Article
- The Clearance-Centered Bottleneck in Alzheimer's Disease: From Coupled Glymphatic-Lymphatic Circuits to Therapeutic Opportunities.Molecular neurobiology · 2026Review
- Sex differences in cerebral pulsatility and damping: A 4D flow MRI study.Experimental physiology · 2026Article
- From the past to the present: evolving theories in the pathophysiology of normal pressure hydrocephalus.Journal of neurology, neurosurgery, and psychiatry · 2026Review
- Modeling Pressure-Dependent Wave and Vessel Compliance in the Brain Following Middle Cerebral Artery Occlusion.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability.bioRxiv : the preprint server for biology · 2025Article
- HyPER: Region-specific hypersampling of fMRI to resolve low-frequency, respiratory, and cardiac pulsations, revealing age-related differences.NeuroImage · 2025Article
- Ultrafast fMRI detects age-related changes in harmonics of cardiac pulsations in the brain at 7 T.bioRxiv : the preprint server for biology · 2025Article
- Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.Experimental physiology · 2025Review
- Simultaneous Assessment of Arterial Pulsatility Across Multiple Segments of Cerebral Arteries Using Multiband Dual-VENC Phase-Contrast MRI.NMR in biomedicine · 2025Article
- Blood flow in the human cerebral cortex: Large-scale pial vascularization and 1D simulation.PLoS computational biology · 2025Article
- Biological sex influences relationships between cerebral pulsatility and white matter hyperintensities in aging adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- MVP-VSASL: measuring MicroVascular Pulsatility using velocity-selective arterial spin labeling.Magnetic resonance in medicine · 2025Article
- Regional cerebral pulsatile hemodynamics during isocapnic and poikilocapnic hyperthermia in young men.Physiological reports · 2025Article
- Covert cerebrospinal fluid dynamics dysfunction: evolution from conventional to innovative therapies.Frontiers in neurology · 2025Review
- Characterizing the spatial patterns and determinants of cerebrospinal fluid pseudorandom flow in the human brain with low b-value diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
24 more citing papers are in PubMed but not listed here.
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7 authors at 1 institution in 1 country.
Funding
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Abstract
Excessive pulsatile flow caused by aortic stiffness is thought to be a contributing factor for several cerebrovascular diseases. The main purpose of this study was to describe the dampening of the pulsatile flow from the proximal to the distal cerebral arteries, the effect of aging and sex, and its correlation to aortic stiffness. Forty-five healthy elderly (mean age 71 years) and 49 healthy young (mean age 25 years) were included. Phase-contrast magnetic resonance imaging was used for measuring blood flow pulsatility index and dampening factor (proximal artery pulsatility index/distal artery pulsatility index) in 21 cerebral and extra-cerebral arteries. Aortic stiffness was measured as aortic pulse wave velocity. Cerebral arterial pulsatility index increased due to aging and this was more pronounced in distal segments of cerebral arteries. There was no difference in pulsatility index between women and men. Dampening of pulsatility index was observed in all cerebral arteries in both age groups but was significantly higher in young subjects than in elderly. Pulse wave velocity was not correlated with cerebral arterial pulsatility index. The increased pulsatile flow in elderly together with reduced dampening supports the pulse wave encephalopathy theory, since it implies that a higher pulsatile flow is reaching distal arterial segments in older subjects.
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