Evidence map›Paper›PMID 26823438›Full record

ArticleAmerican journal of epidemiology2016

Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women.

Todd R Sponholtz, Julie R Palmer, Lynn Rosenberg, Elizabeth E Hatch, Lucile L Adams-Campbell, Lauren A Wise

Abstract read
In one paragraph

Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Risk factors for endometrial cancer in Black women.Cancer causes & control : CCC · 2023
    Article
  8. Risk assessment for endometrial cancer in women with abnormal vaginal bleeding: Results from the prospective IETA-1 cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022
    Observational
  9. Article
  10. Visceral obesity and incident cancer and cardiovascular disease: An integrative review of the epidemiological evidence.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Todd R Sponholtz
Julie R Palmer
Lynn Rosenberg
Elizabeth E Hatch
Lucile L Adams-Campbell
Lauren A Wise

Funding

FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7M
A Follow-up Study for Causes of Cancer in Black WomenUM1CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 2012 to 2017
$13.7M
Endometrial cancer in black womenR03CA169888 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2013 to 2014
$123k
NCI NIH HHS R01 CA058420NCI NIH HHS R01-CA58420NCI NIH HHS R03 CA169888NCI NIH HHS R03-CA169888NCI NIH HHS UM1 CA164974NCI NIH HHS UM1-CA164974
6 · The paper itself

Abstract

Total and abdominal obesity, as well as metabolic factors such as type 2 diabetes, have been associated with a higher risk of endometrial cancer in white women. It remains unclear to what extent these factors influence the risk of endometrial cancer in black women. We followed 47,557 participants from the Black Women's Health Study for incident endometrial cancer from 1995 through 2013 (n = 274). We used Cox regression models to estimate incidence rate ratios and 95% confidence intervals while accounting for potential confounders. Incidence rate ratios for body mass indices (weight (kg)/height (m)(2)) of 25.0-29.9, 30.0-34.9, 35.0-39.9, and ≥40.0 versus those <25.0 were 1.00 (95% confidence interval (CI): 0.67, 1.48), 1.49 (95% CI: 0.97, 2.30), 2.16 (95% CI: 1.34, 3.49), and 3.60 (95% CI: 2.24, 5.78), respectively (Ptrend <0.0001). A high weight-to-height ratio was also associated with a higher risk (for the highest quartile vs. the lowest, incidence rate ratio = 2.83, 95% CI: 1.77, 4.53), as was type 2 diabetes mellitus (incidence rate ratio = 1.52, 95% CI: 1.04, 2.21). Positive associations with measures of central adiposity (waist circumference, waist-to-hip ratio, and waist-to-height ratio) and hypertension were attenuated after we controlled for body mass index. Total adiposity was an independent risk factor for endometrial cancer among black women and appeared to explain most of the associations seen with other adiposity measures and metabolic factors.

Indexed as

AdiposityAdultBlack or African AmericanBody Mass IndexDiabetes Mellitus, Type 2Endometrial NeoplasmsFemaleHumansHypercholesterolemiaHypertensionIncidenceMiddle AgedObesity, AbdominalProspective StudiesRisk FactorsUnited StatesAfrican Americansdiabetesendometrial cancerobesityprospective studieswomenwomen's health

Identifiers

PMID26823438
PMCPMC4753280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.