ArticleScience (New York, N.Y.)2016
Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction.
Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Evolution and regulation of animal sex chromosomes.Nature reviews. Genetics · 2025Review
- Article
- The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.PLoS genetics · 2023Article
- Two acquired mouse Y chromosome-linked genes, Prssly and Teyorf1, are dispensable for male fertility‡.Biology of reproduction · 2022Article
- Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.Biology of reproduction · 2022Article
- Mammalian X-chromosome inactivation: proposed role in suppression of the male programme in genetic females.Journal of genetics · 2022Article
- Review
- Review
- Distinct roles of haspin in stem cell division and male gametogenesis.Scientific reports · 2021Article
- Effects of the Sex Chromosome Complement, XX, XO, or XY, on the Transcriptome and Development of Mouse Oocytes During Follicular Growth.Frontiers in genetics · 2021Article
- Article
- Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals.Genome biology and evolution · 2020Article
- Germ cell-intrinsic effects of sex chromosomes on early oocyte differentiation in mice.PLoS genetics · 2020Article
- Mechanisms of tissue and cell-type specificity in heritable traits and diseases.Nature reviews. Genetics · 2020Review
- Y chromosome in health and diseases.Cell & bioscience · 2020Review
- DoesFrontiers in oncology · 2020Article
- Reconstitution of male germline cell specification from mouse embryonic stem cells using defined factors in vitro.Cell death and differentiation · 2019Article
- The virtuous cycle of human genetics and mouse models in drug discovery.Nature reviews. Drug discovery · 2019Review
- Alterations of sex determination pathways in the genital ridges of males with limited Y chromosome genes†.Biology of reproduction · 2019Article
- Rescue ofGenes · 2019Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian Y chromosome is considered a symbol of maleness, as it encodes a gene driving male sex determination, Sry, as well as a battery of other genes important for male reproduction. We previously demonstrated in the mouse that successful assisted reproduction can be achieved when the Y gene contribution is limited to only two genes, Sry and spermatogonial proliferation factor Eif2s3y. Here, we replaced Sry by transgenic activation of its downstream target Sox9, and Eif2s3y, by transgenic overexpression of its X chromosome-encoded homolog Eif2s3x. The resulting males with no Y chromosome genes produced haploid male gametes and sired offspring after assisted reproduction. Our findings support the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.