ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2016
Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- The effect of adding colostrum or sodium butyrate to the diet on the intestinal barrier of weaned piglets.PloS one · 2026Article
- Efficacy and Safety of Orogastric vs. Nasogastric Tube Feeding in Preterm Infants: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2024Review
- Skeletal consequences of preterm birth in pigs as a model for preterm infants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Gut development following insulin-like growth factor-1 supplementation to preterm pigs.Pediatric research · 2024Article
- Effects of Weaning Age and Creep Feed Type on Growth Performance and Gut Maturation in Weaned Piglets.Animals : an open access journal from MDPI · 2023Article
- Nomogram for predicting fulminant necrotizing enterocolitis.Pediatric surgery international · 2023Article
- Review
- Early Enteral Feeding in Preterm Infants: A Narrative Review of the Nutritional, Metabolic, and Developmental Benefits.Nutrients · 2021Review
- Exocrine Pancreatic Maturation in Pre-term and Term Piglets Supplemented With Bovine Colostrum.Frontiers in nutrition · 2021Article
- Sex-Specific Survival, Growth, Immunity and Organ Development in Preterm Pigs as Models for Immature Newborns.Frontiers in pediatrics · 2021Article
- Organ Growth and Intestinal Functions of Preterm Pigs Fed Low and High Protein Formulas With or Without Supplemental Leucine or Hydroxymethylbutyrate as Growth Promoters.Frontiers in nutrition · 2021Article
- Gluten-Free Casein-Free Diet for Autism Spectrum Disorders: Can It Be Effective in Solving Behavioural and Gastrointestinal Problems?The Eurasian journal of medicine · 2020Review
- Rapid Gut Adaptation to Preterm Birth Involves Feeding-Related DNA Methylation Reprogramming of Intestinal Genes in Pigs.Frontiers in immunology · 2020Article
- Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets.American journal of physiology. Endocrinology and metabolism · 2019Article
- Metabolism of Milk Oligosaccharides in Preterm Pigs Sensitive to Necrotizing Enterocolitis.Frontiers in nutrition · 2019Article
- Article
- Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age.EFSA journal. European Food Safety Authority · 2017Article
- Delayed development of systemic immunity in preterm pigs as a model for preterm infants.Scientific reports · 2016Article
- Limited effects of preterm birth and the first enteral nutrition on cerebellum morphology and gene expression in piglets.Physiological reports · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preterm infants often tolerate full enteral nutrition a few weeks after birth but it is not known how this is related to gut maturation. Using pigs as models, we hypothesized that intestinal structure and digestive function are similar in preterm and term individuals at 3-4 wk after birth and that early enteral nutrition promotes maturation. Preterm or term cesarean-delivered pigs were fed total parenteral nutrition, or partial enteral nutrition [Enteral (Ent), 16-64 ml·kg(-1)·day(-1) of bovine colostrum] for 5 days, followed by full enteral milk feeding until day 26 The intestine was collected for histological and biochemical analyses at days 0, 5, and 26 (n = 8-12 in each of 10 treatment groups). Intestinal weight (relative to body weight) was reduced in preterm pigs at 0-5 days but ENT feeding stimulated the mucosal volume and peptidase activities. Relative to term pigs, mucosal volume remained reduced in preterm pigs until 26 days although plasma glucagon-like peptide 2 (GLP-2) and glucose-dependent insulin-trophic peptide (GIP) levels were increased. Preterm pigs also showed reduced hexose absorptive capacity and brush-border enzyme (sucrase, maltase) activities at 26 days, relative to term pigs. Intestinal structure shows a remarkable growth adaptation in the first week after preterm birth, especially with enteral nutrition, whereas some digestive functions remain immature until at least 3-4 wk. It is important to identify feeding regimens that stimulate intestinal maturation in the postnatal period of preterm infants because some intestinal functions may show long-term developmental delay.
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