Evidence map›Paper›PMID 26822582›Full record

Trial reportEuropean journal of applied physiology2016

Low-intensity resistance training with blood flow restriction improves vascular endothelial function and peripheral blood circulation in healthy elderly people.

Ryosuke Shimizu, Kazuki Hotta, Shuhei Yamamoto, Takuya Matsumoto, Kentaro Kamiya, Michitaka Kato, Nobuaki Hamazaki, Daisuke Kamekawa, Ayako Akiyama, Yumi Kamada and 2 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 95 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 11 pooled it
30.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03540147 naterminatednot on this mapstarted 2018, after this paper: background citation

The Impact of Blood Flow Restriction (BFR) on Exercise and Hemodynamic Responses

TypeinterventionalSponsorUniversity of Texas at AustinRan2018 to 2019Enrolled20ConditionsExercise Training, Hemodynamic ResponseArmsHokanson Cuffs, BStrong Bands
NCT04248413 nawithdrawnnot on this mapstarted 2022, after this paper: background citation

Blood Flow Restriction Training Following Acute Shoulder Injury In Baseball Players: Assessment of Efficacy in Return to Sport

TypeinterventionalSponsorWake Forest University Health SciencesRan2022 to 2022Enrolled0ConditionsMusculoskeletal InjuryArmsBlood Flow Restriction Therapy, Standard physical rehabilitation
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 11 syntheses or guidelines pooled it, 180 citations in OpenAlex.

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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ryosuke ShimizuDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan.
Kazuki HottaDepartment of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306, USA.
Shuhei YamamotoDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan.
Takuya MatsumotoDepartment of Rehabilitation, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-ku, 108-8642, Japan.
Kentaro KamiyaDepartment of Rehabilitation, Kitasato University Hospital, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0375, Japan.
Michitaka KatoDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan.
Nobuaki HamazakiDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan.
Daisuke KamekawaDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan.
Ayako AkiyamaDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan.
Yumi KamadaDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan.
Shinya TanakaDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan.
Takashi MasudaDepartment of Angiology and Cardiology, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373, Japan. tak9999@med.kitasato-u.ac.jp.
Kitasato University · JPKitasato University Hospital · JPFlorida State University · USShinshu University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe present study aimed to investigate the effects of low-intensity resistance training with blood flow restriction (BFR resistance training) on vascular endothelial function and peripheral blood circulation.

methodsForty healthy elderly volunteers aged 71 ± 4 years were divided into two training groups. Twenty subjects performed BFR resistance training (BFR group), and the remaining 20 performed ordinary resistance training without BFR. Resistance training was performed at 20 % of each estimated one-repetition maximum for 4 weeks. We measured lactate (Lac), norepinephrine (NE), vascular endothelial growth factor (VEGF) and growth hormone (GH) before and after the initial resistance training. The reactive hyperemia index (RHI), von Willebrand factor (vWF) and transcutaneous oxygen pressure in the foot (Foot-tcPO2) were assessed before and after the 4-week resistance training period.

resultsLac, NE, VEGF and GH increased significantly from 8.2 ± 3.6 mg/dL, 619.5 ± 243.7 pg/mL, 43.3 ± 15.9 pg/mL and 0.9 ± 0.7 ng/mL to 49.2 ± 16.1 mg/dL, 960.2 ± 373.7 pg/mL, 61.6 ± 19.5 pg/mL and 3.1 ± 1.3 ng/mL, respectively, in the BFR group (each P < 0.01). RHI and Foot-tcPO2 increased significantly from 1.8 ± 0.2 and 62.4 ± 5.3 mmHg to 2.1 ± 0.3 and 68.9 ± 5.8 mmHg, respectively, in the BFR group (each P < 0.01). VWF decreased significantly from 175.7 ± 20.3 to 156.3 ± 38.1 % in the BFR group (P < 0.05).

conclusionsBFR resistance training improved vascular endothelial function and peripheral blood circulation in healthy elderly people.

Indexed as

Regional Blood FlowAgedAged, 80 and overEndothelium, VascularFemaleGrowth HormoneHemodynamicsHumansLactic AcidMaleNorepinephrineResistance TrainingVascular Endothelial Growth Factor AGrowth HormoneLactic AcidNorepinephrineVascular Endothelial Growth Factor AHypoxiaLow-intensity exerciseMuscle strengthNeurohumoral factorsPeripheral circulationReactive hyperemia

Identifiers

PMID26822582
OpenAlexW2292512244

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.