ArticleInfluenza and other respiratory viruses2016
Serotype and genetic diversity of human rhinovirus strains that circulated in Kenya in 2008.
Article in Influenza and other respiratory viruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 18 citations in OpenAlex.
- Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal.Journal of medical virology · 2019Trial
- Spatio-temporal distribution of rhinovirus types in Kenya: a retrospective analysis, 2014.Scientific reports · 2024Article
- Review
- Molecular epidemiology of Enteroviruses and Rhinoviruses in patients with acute respiratory infections in Yaounde, Cameroon.Influenza and other respiratory viruses · 2021Article
- Genotypes of rhinovirus detected among children in two communities of South-West Nigeria.Virus genes · 2021Article
- Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013-2015.Frontiers in microbiology · 2018Article
- Ribonuclease fromBioMed research international · 2017Article
- Serotype and genetic diversity of human rhinovirus strains that circulated in Kenya in 2008.Influenza and other respiratory viruses · 2016Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman rhinoviruses (HRVs) are a well-established cause of the common cold and recent studies indicated that they may be associated with severe acute respiratory illnesses (SARIs) like pneumonia, asthma, and bronchiolitis. Despite global studies on the genetic diversity of the virus, the serotype diversity of these viruses across diverse geographic regions in Kenya has not been characterized.
objectivesThis study sought to characterize the serotype diversity of HRV strains that circulated in Kenya in 2008.
methodsA total of 517 archived nasopharyngeal samples collected in a previous respiratory virus surveillance program across Kenya in 2008 were selected. Participants enrolled were outpatients who presented with influenza-like (ILI) symptoms. Real-time RT-PCR was employed for preliminary HRV detection. HRV-positive samples were amplified using RT-PCR and thereafter the nucleotide sequences of the amplicons were determined followed by phylogenetic analysis.
resultsTwenty-five percent of the samples tested positive for HRV. Phylogenetic analysis revealed that the Kenyan HRVs clustered into three main species comprising HRV-A (54%), HRV-B (12%), and HRV-C (35%). Overall, 20 different serotypes were identified. Intrastrain sequence homology among the Kenyan strains ranged from 58% to 100% at the nucleotide level and 55% to 100% at the amino acid level.
conclusionThese results show that a wide range of HRV serotypes with different levels of nucleotide variation were present in Kenya. Furthermore, our data show that HRVs contributed substantially to influenza-like illness in Kenya in 2008.
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