ArticleBMC genetics2016
Genetic determinants of pig birth weight variability.
Article in BMC genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Integrated environmental and genomic analysis reveals the drivers and genetic mechanisms of agro-climatic adaptation in geese.BMC genomics · 2026Article
- Genes and Gene Functions Associated with Morphological, Productive, Reproductive, and Carcass Quality Traits in Pigs: A Functional Bioinformatics Approach.Current issues in molecular biology · 2026Article
- Genome-Wide Association Study of Birth Wool Length, Birth Weight, and Head Color in Chinese Tan Sheep Through Whole-Genome Re-Sequencing.Animals : an open access journal from MDPI · 2024Article
- Genome wide association study of thyroid hormone levels following challenge with porcine reproductive and respiratory syndrome virus.Frontiers in genetics · 2023Article
- Genome-Wide Association Analysis Reveals Novel Loci Related with Visual Score Traits in Nellore Cattle Raised in Pasture-Based Systems.Animals : an open access journal from MDPI · 2022Article
- Profiling of open chromatin in developing pig (Sus scrofa) muscle to identify regulatory regions.G3 (Bethesda, Md.) · 2022Article
- Evaluation of the phenotypic and genomic background of variability based on litter size of Large White pigs.Genetics, selection, evolution : GSE · 2022Article
- Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats.Frontiers in veterinary science · 2021Article
- Genome-Wide Association Study and Fine Mapping Reveals Candidate Genes for Birth Weight of Yorkshire and Landrace Pigs.Frontiers in genetics · 2020Article
- Impact of merging commercial breeding lines on the genetic diversity of Landrace pigs.Genetics, selection, evolution : GSE · 2019Article
- First Genome-wide Association Analysis for Growth Traits in the Largest Coral Reef-Dwelling Bony Fishes, the Giant Grouper (Epinephelus lanceolatus).Marine biotechnology (New York, N.Y.) · 2019Article
- Genomic analysis reveals genes affecting distinct phenotypes among different Chinese and western pig breeds.Scientific reports · 2018Article
- Genomic regions underlying uniformity of yearling weight in Nellore cattle evaluated under different response variables.BMC genomics · 2018Article
- Identification of novel genes significantly affecting growth in catfish through GWAS analysis.Molecular genetics and genomics : MGG · 2018Article
- Genome-Wide Association Study of Piglet Uniformity and Farrowing Interval.Frontiers in genetics · 2017Article
- The papers presented at 7th Young Scientists School "Systems Biology and Bioinformatics" (SBB'15): Introductory Note. Introduction.BMC genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPiglet birth weight variability, a trait also known as the within-litter homogeneity of birth weight, reflects the sow's prolificacy, because it is positively genetically correlated with preweaning mortality but negatively correlated with the mean growth of piglets during sucking. In addition, the maternal additive genetic variance and heritability has been found exist for this trait, thus, reduction in the variability of piglet birth weight to improve the sow prolificacy is possible by selective breeding.
resultsWe performed a genome wide association study (GWAS) in 82 sows with extreme standard deviation of birth weights within the first parity to identify significant SNPs, and finally 266 genome-wide significant SNPs (p < 0.01) were identified. These SNPs were mainly enriched on chromosome 7, 1, 13, 14, 15 and 18. We further scanned genes of the top 50 SNPs with the lowest p values and found some genes involved in plasma glucose homeostasis (GLP1R) and lipid metabolism as well as maternal-fetal lipid transport (AACS, APOB, OSBPL10 and LRP1B) which may contribute to the birth weight variability trait.
conclusionsBirth weight variability trait has a low heritability. It is not easy to get significant signal by GWAS using small sample size. Herein, we identified some candidate chromosome regions especially chromosome 7 and suggested five genes which may provide some information for the further study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.