SynthesisBMC gastroenterology2016
Surgical outcomes of hepatocellular carcinoma with biliary tumor thrombus: a systematic review.
Synthesis in BMC gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Effect of oral probiotics on postoperative nutrition level of patients with liver cancer.Open medicine (Warsaw, Poland) · 2026Article
- Radiomics analysis of R2* maps to predict early recurrence of single hepatocellular carcinoma after hepatectomy.Frontiers in oncology · 2024Article
- Phase Attention Model for Prediction of Early Recurrence of Hepatocellular Carcinoma With Multi-Phase CT Images and Clinical Data.Frontiers in radiology · 2022Article
- A nomogram based on combining systemic and hepatic inflammation markers for predicting microscopic bile duct tumour thrombus in hepatocellular carcinoma.BMC cancer · 2021Article
- Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study.Frontiers in oncology · 2021Article
- Postoperative Adjuvant Transarterial Chemoembolization Improves Short-Term Prognosis of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus: A Propensity-Score Matching Study.Cancer management and research · 2020Article
- Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIPCell death & disease · 2018Article
- Article
- Clinical role and biological function of CDK5 in hepatocellular carcinoma: A study based on immunohistochemistry, RNA-seq andOncotarget · 2017Article
- Prognostic value of integrin variants and expression in post-operative patients with HBV-related hepatocellular carcinoma.Oncotarget · 2017Article
- A single institution report of 19 hepatocellular carcinoma patients with bile duct tumor thrombus.Journal of hepatocellular carcinoma · 2017Article
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5 authors.
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Abstract
backgroundHepatocellular carcinoma (HCC) with biliary tumor thrombus (BTT) is rare and its impact on postoperative prognosis remains controversial. The aim of this study was to evaluate the published evidence concerning the outcome of surgical resection of HCC with BTT.
methodsEligible studies were identified by searching PubMed and reviewed systematically. Comparisons of the clinicopathologic features and surgical outcomes for HCC patients with or without BTT were analyzed using meta-analytical techniques.
resultsTwenty retrospective studies containing 598 patients that met the selection criteria were included for review. The perioperative mortality was 2.1 % (range, 0-10 %), and the median 5-year overall survival (OS) was 24 % (range, 0-48 %) with a recurrence rate of 63.9 % (range, 42-91 %). Pooled analysis of 13 comparative studies showed that HCC patients with BTT had a higher incidence of vascular invasion (odds ratio [OR]: 4.70, 95 % CI: 2.90-7.60; P <0.001), a higher frequency of poor differentiation (OR: 2.07, 95 % CI: 1.23-3.49; P = 0.006), and a shorter 5-year OS rate (OR: 0.31, 95 % CI: 0.21-0.64; P <0.001) than those without BTT.
conclusionsAlthough HCC with BTT has more aggressive biological characteristics and is an indicator of poor prognosis, surgical resection can still provide long-term survival for some patients.
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