ReviewStem cell research & therapy2016
Combining regenerative medicine strategies to provide durable reconstructive options: auricular cartilage tissue engineering.
Review in Stem cell research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Evolution and Hotspots in Autologous Ear Reconstruction: A Bibliometric Analysis of the 100 Most-cited Studies.Plastic and reconstructive surgery. Global open · 2026Article
- Biological Impact of Extrusion Bioprinting Nasoseptal Chondrocytes for Tissue Engineering Applications.Journal of functional biomaterials · 2026Article
- Auricular cartilage tissue engineering: from making cartilage to regenerating a shape-stable elastic organ.Frontiers in bioengineering and biotechnology · 2026Article
- Adipose-mesenchymal stem cells enhance the formation of auricular cartilage in vitro and in vivo.Stem cells translational medicine · 2025Article
- Small spheroids for head and neck cartilage tissue engineering.Scientific reports · 2024Article
- Adipose-derived mesenchymal stem cell-incorporated PLLA porous microspheres for cartilage regeneration.Animal models and experimental medicine · 2024Article
- 3D printing tissue-engineered scaffolds for auricular reconstruction.Materials today. Bio · 2024Review
- Endocrine Petrified Ear: Associated Endocrine Conditions in Auricular Calcification/Ossification (A Sample-Focused Analysis).Diagnostics (Basel, Switzerland) · 2024Review
- Evaluation of Bioprinted Autologous Cartilage Grafts in an Immunocompetent Rabbit Model.Advanced therapeutics · 2024Article
- Hydrogel Based on Chitosan/Gelatin/Poly(Vinyl Alcohol) for In Vitro Human Auricular Chondrocyte Culture.Polymers · 2024Article
- Article
- Nasoseptal chondroprogenitors isolated through fibronectin-adherence confer no biological advantage for cartilage tissue engineering compared to nasoseptal chondrocytes.Frontiers in bioengineering and biotechnology · 2024Article
- Alginate Conjugation Increases Toughness in Auricular Chondrocyte Seeded Collagen Hydrogels.Bioengineering (Basel, Switzerland) · 2023Article
- The application and progress of stem cells in auricular cartilage regeneration: a systematic review.Frontiers in cell and developmental biology · 2023Review
- Article
- 3D-printed high-density polyethylene scaffolds with bioactive and antibacterial layer-by-layer modification for auricle reconstruction.Materials today. Bio · 2022Article
- Article
- Auricular reconstruction: where are we now? A critical literature review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Review
- Multiscale Strain Transfer in Cartilage.Frontiers in cell and developmental biology · 2022Review
- M1-like macrophage contributes to chondrogenesis in vitro.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Recent advances in regenerative medicine place us in a unique position to improve the quality of engineered tissue. We use auricular cartilage as an exemplar to illustrate how the use of tissue-specific adult stem cells, assembly through additive manufacturing and improved understanding of postnatal tissue maturation will allow us to more accurately replicate native tissue anisotropy. This review highlights the limitations of autologous auricular reconstruction, including donor site morbidity, technical considerations and long-term complications. Current tissue-engineered auricular constructs implanted into immune-competent animal models have been observed to undergo inflammation, fibrosis, foreign body reaction, calcification and degradation. Combining biomimetic regenerative medicine strategies will allow us to improve tissue-engineered auricular cartilage with respect to biochemical composition and functionality, as well as microstructural organization and overall shape. Creating functional and durable tissue has the potential to shift the paradigm in reconstructive surgery by obviating the need for donor sites.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.