ArticleJournal of translational medicine2016
Human endometrial regenerative cells attenuate renal ischemia reperfusion injury in mice.
Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Human Menstrual Blood-Derived Stem Cells Protect against Tacrolimus-Induced Islet Dysfunction via Cystathionine β-Synthase Mediated IL-6/STAT3 Inactivation.Biomolecules · 2024Article
- Body fluid-derived stem cells - an untapped stem cell source in genitourinary regeneration.Nature reviews. Urology · 2023Review
- Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using deep-learning-based semantic segmentation in histology.Biology open · 2023Article
- Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome.Stem cell research & therapy · 2022Article
- Endometrium Derived Stem Cells as Potential Candidates in Nervous System Repair.Annals of biomedical engineering · 2022Review
- Therapeutic role of uterine-derived stem cells in acute kidney injury.Stem cell research & therapy · 2022Article
- Endometrial Regenerative Cell-Derived Conditioned Medium Alleviates Experimental Colitis.Stem cells international · 2022Article
- Endometrial regenerative cells with galectin-9 high-expression attenuate experimental autoimmune hepatitis.Stem cell research & therapy · 2021Article
- Endometrial stem/progenitor cells and their roles in immunity, clinical application, and endometriosis.Stem cell research & therapy · 2021Review
- Menstrual Blood-Derived Endometrial Stem Cells' Impact for the Treatment Perspective of Female Infertility.International journal of molecular sciences · 2021Article
- IL-1β pre-stimulation enhances the therapeutic effects of endometrial regenerative cells on experimental colitis.Stem cell research & therapy · 2021Article
- CD73 expression is critical to therapeutic effects of human endometrial regenerative cells in inhibition of cardiac allograft rejection in mice.Stem cells translational medicine · 2021Article
- Intrinsic Angiogenic Potential and Migration Capacity of Human Mesenchymal Stromal Cells Derived from Menstrual Blood and Bone Marrow.International journal of molecular sciences · 2020Article
- Mesenchymal Stromal Cell Uses for Acute Kidney Injury-Current Available Data and Future Perspectives: A Mini-Review.Frontiers in immunology · 2020Review
- Stromal Cell-Derived Factor-1 Enhances the Therapeutic Effects of Human Endometrial Regenerative Cells in a Mouse Sepsis Model.Stem cells international · 2020Article
- IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury.Stem cells international · 2020Article
- SDF-1/CXCR4 axis enhances the immunomodulation of human endometrial regenerative cells in alleviating experimental colitis.Stem cell research & therapy · 2019Article
- Therapeutic potential of menstrual blood-derived endometrial stem cells in cardiac diseases.Cellular and molecular life sciences : CMLS · 2019Review
- PD-L1 is required for human endometrial regenerative cells-associated attenuation of experimental colitis in mice.American journal of translational research · 2019Article
- Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine.Stem cell research & therapy · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometrial regenerative cells (ERCs) is an attractive novel type of adult mesenchymal stem cells that can be non-invasively obtained from menstrual blood and are easily replicated at a large scale without tumorigenesis. We have previously reported that ERCs exhibit unique immunoregulatory properties in experimental studies in vitro and in vivo. In this study, the protective effects of ERCs on renal ischemia-reperfusion injury (IRI) were examined.
methodsRenal IRI in C57BL/6 mice was induced by clipping bilateral renal pedicles for 30 min, followed by reperfusion for 48 h. ERCs were isolated from healthy female menstrual blood, and were injected (1 million/mouse, i.v.) into mice 2 h prior to IRI induction. Renal function, pathological and immunohistological changes, cell populations and cytokine profiles were evaluated after 48 h of renal reperfusion.
resultsHere, we showed that as compared to untreated controls, administration of ERCs effectively prevented renal damage after IRI, indicated by better renal function and less pathological changes, which were associated with increased serum levels of IL-4, but decreased levels of TNF-α, IFN-γ and IL-6. Also, ERC-treated mice displayed significantly less splenic and renal CD4(+) and CD8(+) T cell populations, while the percentage of splenic CD4(+)CD25(+) regulatory T cells and infiltrating M2 macrophages in the kidneys were significantly increased in ERC-treated mice.
conclusionsThis study demonstrates that the novel anti-inflammatory and immunoregulatory effects of ERCs are associated with attenuation of renal IRI, suggesting that the unique features of ERCs may make them a promising candidate for cell therapies in the treatment of ischemic acute kidney injury in patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.