Evidence map›Paper›PMID 26822009›Full record

ArticleNeurogastroenterology and motility2016

Pressure topography metrics for high-resolution pharyngeal-esophageal manofluorography-a normative study of younger and older adults.

N Nativ-Zeltzer, J A Logemann, S G Zecker, P J Kahrilas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. A systematic review of current methodology of high resolution pharyngeal manometry with and without impedance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019
    Pooled it
  2. Evaluation of post-laryngectomy dysphagia rehabilitation using High-Resolution impedance manometry: an exploratory study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

N Nativ-ZeltzerDepartment of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
J A LogemannDepartment of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
S G ZeckerDepartment of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
P J KahrilasDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Northwestern University · US

Funding

THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASER01DK056033 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAHRILAS, PETER JAMES · 2001 to 2015
$4.1M
NIDDK NIH HHS R01 DK056033
6 · The paper itself

Abstract

backgroundWe aimed to define normative values for novel pressure topography metrics for high-resolution pharyngeal-esophageal manofluorography. The effects of age, gender, and bolus properties were examined.

methodsConcurrent high-resolution manometry (HRM) and videofluoroscopy data were collected from 22 younger (aged 21-40) and 22 older (aged 60-80) healthy subjects. Pressure topography was analyzed by correlating pressure domains with videofluoroscopic events. Nine pressure topography metrics of the pharyngeal and proximal esophageal swallow were extracted; four of these were also compared with previously obtained esophageal HRM studies to assess the effects of catheter diameter. KEY

resultsOlder individuals exhibited more vigorous contractility in the pharynx than did younger subjects with all bolus types, but the greatest values for both groups were with effortful swallow and on that measure the age groups were similar. Upper esophageal sphincter (UES) intrabolus pressure during sphincter opening was also greater in the older subjects. Some gender differences were observed, particularly related to proximal esophageal contractile vigor. Bolus consistency had no consistent effect. Studies using the larger catheter diameter resulted in significantly greater contractile vigor in the UES and proximal esophagus. CONCLUSIONS & INFERENCES: Older adults exhibited more vigorous pharyngeal contractions than young adults, albeit within a similar range of capacity, perhaps reflecting a compensatory response to other age-related physiological changes. Greater UES intrabolus pressures observed during bolus transit in the older group likely reflect reduced UES compliance with age. Normative data on novel HRM metrics collected in this study can serve as a reference for future clinical studies.

Indexed as

AdultAgedAged, 80 and overDeglutitionEsophagusFemaleFluoroscopyHumansMaleManometryMiddle AgedMuscle ContractionPharynxPressureVideo RecordingYoung Adultdysphagiahigh-resolution manometrymano-fluorographypharyngeal swallowupper esophageal sphincter

Identifiers

PMID26822009
PMCPMC4892368
OpenAlexW2294269414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.