ArticleScientific reports2016
Interplay between type IV pili activity and exopolysaccharides secretion controls motility patterns in single cells of Myxococcus xanthus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Effect of biofilm lifestyle caused by water matric potential on invasion of exogenous plasmid.ISME communications · 2026Article
- Article
- Pseudomonas aeruginosa senses exopolysaccharide trails using type IV pili and adhesins during biofilm formation.Nature microbiology · 2025Article
- Recent progress on the biological degradation and solubilization of coal.Biodegradation · 2025Review
- Genetic components ofFrontiers in microbiology · 2023Article
- Porous Pellicle Formation of a Filamentous Bacterium,Applied and environmental microbiology · 2022Article
- A review on pilus assembly mechanisms in Gram-positive and Gram-negative bacteria.Cell surface (Amsterdam, Netherlands) · 2022Article
- A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria.eLife · 2021Article
- Exopolysaccharides from bacteria and fungi: current status and perspectives in Africa.Heliyon · 2020Review
- Two genomic regions encoding exopolysaccharide production systems have complementary functions in B. cereus multicellularity and host interaction.Scientific reports · 2020Article
- Dynamics of Solitary Predation by Myxococcus xanthus on Escherichia coli Observed at the Single-Cell Level.Applied and environmental microbiology · 2020Article
- Type IV pili: dynamics, biophysics and functional consequences.Nature reviews. Microbiology · 2019Review
- Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes.Journal of visualized experiments : JoVE · 2017Article
- Colony Expansion of Socially Motile Myxococcus xanthus Cells Is Driven by Growth, Motility, and Exopolysaccharide Production.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Myxococcus xanthus performs coordinated social motility of cell groups through the extension and retraction of type IV pili (TFP) on solid surfaces, which requires both TFP and exopolysaccharides (EPS). By submerging cells in a liquid medium containing 1% methylcellulose, M. xanthus TFP-driven motility was induced in isolated cells and independently of EPS. We measured and analyzed the movements of cells using community tracking algorithms, which combine single-cell resolution with statistics from large sample populations. Cells without significant multi-cellular social interactions have surprisingly complex behaviors: EPS(-) cells exhibited a pronounced increase in the tendency to stand vertically and moved with qualitatively different characteristics than other cells. A decrease in the EPS secretion of cells correlates with a higher instantaneous velocity, but with lower directional persistence in trajectories. Moreover, EPS(-) cells do not adhere to the surface as strongly as wild-type and EPS overproducing cells, and display a greater tendency to have large deviations between the direction of movement and the cell axis, with cell velocity showing only minimal dependence on the direction of movement. The emerging picture is that EPS does not simply provide rheological resistance to a single mechanism but rather that the availability of EPS impacts motility pattern.
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Registered trials
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