Evidence map›Paper›PMID 26821863›Full record

ReviewChemical reviews2016

Synthetic Biomaterials from Metabolically Derived Synthons.

Nicole G Ricapito, Cynthia Ghobril, Heng Zhang, Mark W Grinstaff, David Putnam

Abstract readReview
In one paragraph

Review in Chemical reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. High dose, dual-release polymeric films for extended surgical bed paclitaxel delivery.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Bioinspired Design Provides High-Strength Benzoxazine Structural Adhesives.Angewandte Chemie (International ed. in English) · 2019
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicole G RicapitoSchool of Chemical and Biomolecular Engineering, Cornell University , Ithaca, New York 14853, United States.
Cynthia GhobrilDepartment of Chemistry, Boston University , Boston, Massachusetts 02215, United States.
Heng ZhangDepartment of Chemistry, Boston University , Boston, Massachusetts 02215, United States.
Mark W GrinstaffDepartment of Chemistry, Boston University , Boston, Massachusetts 02215, United States.
David PutnamSchool of Chemical and Biomolecular Engineering, Cornell University , Ithaca, New York 14853, United States.

Funding

Translational Research in BiomaterialsT32EB006359 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MARK W. GRINSTAFF, Michelle H Teplensky · 2009 to 2026
$4.2M
Efficacy and Safety of a Novel, Implantable Drug-eluting Film in SarcomaR01EB017722 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI COLSON, YOLONDA L, GRINSTAFF, MARK W. · 2016 to 2019
$1.7M
NIBIB NIH HHS R01 EB017722NIBIB NIH HHS T32 EB006359
6 · The paper itself

Abstract

The utility of metabolic synthons as the building blocks for new biomaterials is based on the early application and success of hydroxy acid based polyesters as degradable sutures and controlled drug delivery matrices. The sheer number of potential monomers derived from the metabolome (e.g., lactic acid, dihydroxyacetone, glycerol, fumarate) gives rise to almost limitless biomaterial structural possibilities, functionality, and performance characteristics, as well as opportunities for the synthesis of new polymers. This review describes recent advances in new chemistries, as well as the inventive use of traditional chemistries, toward the design and synthesis of new polymers. Specific polymeric biomaterials can be prepared for use in varied medical applications (e.g., drug delivery, tissue engineering, wound repair, etc.) through judicious selection of the monomer and backbone linkage.

Indexed as

Amino AcidsBiocompatible MaterialsDihydroxyacetoneGlycerolHydroxy AcidsMolecular StructurePolymersAmino AcidsBiocompatible MaterialsDihydroxyacetoneGlycerolHydroxy AcidsPolymers

Identifiers

PMID26821863
PMCPMC5810137

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.