ArticleScientific reports2016
Normothermic Mouse Functional MRI of Acute Focal Thermostimulation for Probing Nociception.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The neuronal circuits and cellular encoding of thermosensation.Nature reviews. Neuroscience · 2026Review
- The secondary somatosensory cortex gates mechanical and heat sensitivity.Nature communications · 2024Article
- Evaluation of an Adoptive Cellular Therapy-Based Vaccine in a Transgenic Mouse Model of α-synucleinopathy.ACS chemical neuroscience · 2023Article
- Generation of a whole-brain hemodynamic response function and sex-specific differences in cerebral processing of mechano-sensation in mice detected by BOLD fMRI.Frontiers in neuroscience · 2023Article
- Preparation and Monitoring of Small Animals in Renal MRI.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Hardware Considerations for Preclinical Magnetic Resonance of the Kidney.Methods in molecular biology (Clifton, N.J.) · 2021Article
- α-Synuclein Induces Progressive Changes in Brain Microstructure and Sensory-Evoked Brain Function That Precedes Locomotor Decline.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The (Un)Conscious Mouse as a Model for Human Brain Functions: Key Principles of Anesthesia and Their Impact on Translational Neuroimaging.Frontiers in systems neuroscience · 2020Review
- The neural circuits of thermal perception.Current opinion in neurobiology · 2018Review
- A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models.Disease models & mechanisms · 2018Review
- Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain.Brain and neuroscience advances · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combining mouse genomics and functional magnetic resonance imaging (fMRI) provides a promising tool to unravel the molecular mechanisms of chronic pain. Probing murine nociception via the blood oxygenation level-dependent (BOLD) effect is still challenging due to methodological constraints. Here we report on the reproducible application of acute noxious heat stimuli to examine the feasibility and limitations of functional brain mapping for central pain processing in mice. Recent technical and procedural advances were applied for enhanced BOLD signal detection and a tight control of physiological parameters. The latter includes the development of a novel mouse cradle designed to maintain whole-body normothermia in anesthetized mice during fMRI in a way that reflects the thermal status of awake, resting mice. Applying mild noxious heat stimuli to wildtype mice resulted in highly significant BOLD patterns in anatomical brain structures forming the pain matrix, which comprise temporal signal intensity changes of up to 6% magnitude. We also observed sub-threshold correlation patterns in large areas of the brain, as well as alterations in mean arterial blood pressure (MABP) in response to the applied stimulus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.