Evidence map›Paper›PMID 26821815›Full record

ReviewExpert review of clinical immunology2016

Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis.

Jinjung Choi, Carlo Selmi, Patrick S C Leung, Thomas P Kenny, Tania Roskams, M Eric Gershwin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
  2. Review
  3. Elevated Serum Soluble Tim-3 in Primary Biliary Cholangitis: Lack of Correlation with Cytokines, Chemokines, and Clinical Parameters.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
  4. Pathogenesis, Non-Invasive Assessments and Treatment of Hepatic Fibrosis in Autoimmune Liver Diseases.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  5. Article
  6. Review
  7. Roles of Chemokines in Intervertebral Disk Degeneration.Current pain and headache reports · 2024
    Review
  8. Article
  9. Review
  10. [Roles of the CXCR1/CXCL8 axis in abnormal proliferation of bile duct epithelial cells in primary biliary cholangitis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. CXCL12 Signaling in the Tumor Microenvironment.Advances in experimental medicine and biology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 5 countries.

Jinjung Choia Division of Rheumatology, Allergy and Clinical Immunology , University of California Davis , Davis , CA , USA.
Carlo Selmic Rheumatology and Clinical Immunology , Humanitas Research Hospital , Rozzano , Italy.
Patrick S C Leunga Division of Rheumatology, Allergy and Clinical Immunology , University of California Davis , Davis , CA , USA.
Thomas P Kennya Division of Rheumatology, Allergy and Clinical Immunology , University of California Davis , Davis , CA , USA.
Tania Roskamse Translational Cell and Tissue Research , University of Leuven , Leuven , Belgium.
M Eric Gershwina Division of Rheumatology, Allergy and Clinical Immunology , University of California Davis , Davis , CA , USA.
Agency for Quality Assurance and Accreditation Austria · ATCHA University · KRIRCCS Humanitas Research Hospital · ITKU Leuven · BE

Funding

MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSISR37DK039588 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI GERSHWIN, MERRILL E · 2001 to 2010
$3.5M
MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSISR01DK039588 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI GERSHWIN, MERRILL E · 1988 to 2015
$2.0M
NIDDK NIH HHS R01 DK039588NIDDK NIH HHS R37 DK039588
6 · The paper itself

Abstract

Chemokines represent a major mediator of innate immunity and play a key role in the selective recruitment of cells during localized inflammatory responses. Beyond critical extracellular mediators of leukocyte trafficking, chemokines and their cognate receptors are expressed by a variety of resident and infiltrating cells (monocytes, lymphocytes, NK cells, mast cells, and NKT cells). Chemokines represent ideal candidates for mechanistic studies (particularly in murine models) to better understand the pathogenesis of chronic inflammation and possibly become biomarkers of disease. Nonetheless, therapeutic approaches targeting chemokines have led to unsatisfactory results in rheumatoid arthritis, while biologics against pro-inflammatory cytokines are being used worldwide with success. In this comprehensive review we will discuss the evidence supporting the involvement of chemokines and their specific receptors in mediating the effector cell response, utilizing the autoimmune/primary biliary cholangitis setting as a paradigm.

Indexed as

AnimalsAutoimmunityChemokinesCholangitisDisease Models, AnimalHumansImmunity, InnateImmunotherapyLiver Cirrhosis, BiliaryReceptors, ChemokineChemokinesReceptors, Chemokineautoimmune cholangitisbiologicschemokine receptorInnate immunitymonoclonal antibodytolerance breakdown

Identifiers

PMID26821815
PMCPMC4935758
OpenAlexW2287616326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.