Evidence map›Paper›PMID 26821752›Full record

ArticleScientific reports2016

WISP1 mediates hepatic warm ischemia reperfusion injury via TLR4 signaling in mice.

Yao Tong, Xi-Bing Ding, Zhi-Xia Chen, Shu-Qing Jin, Xiang Zhao, Xin Wang, Shu-Ya Mei, Xi Jiang, Lingyu Wang, Quan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yao TongDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Xi-Bing DingDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Zhi-Xia ChenDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Shu-Qing JinDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Xiang ZhaoDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Xin WangDepartment of Anesthesiology, First Clinical College of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
Shu-Ya MeiDepartment of Anesthesiology, School of Medicine, Nanchang University, Nanchang 330031, Jiangxi, China.
Xi JiangDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Lingyu WangDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Quan LiDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Shanghai East Hospital · CNNanchang University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wnt-induced secreted protein-1 (WISP1) is an extracellular matrix protein that has been reported in cancer researches. Our previous studies on WISP1 implied it could be a harmful mediator in septic mice. However, its role in liver ischemia reperfusion (I/R) injury is unknown. This study investigated the effects of WISP1 on liver I/R damage. Male C57BL/6 wild-type mice were used to undergo 60 min segmental (70%) ischemia. WISP1 expression was measured after indicated time points of reperfusion. Anti-WISP1 antibody was injected intraperitoneally to mice. Toll-like receptor 4 (TLR4) knockout mice and TIR-domain-containing adaptor inducing interferon-β (TRIF) knockout mice were adopted in this study. WISP1 was significantly enhanced after 6 h of reperfusion when compared with sham treated mice and significantly decreased either by TLR4 knockout mice or TRIF knockout mice. Anti-WISP1 antibody significantly decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), pathological changes and pro-inflammatory cytokine levels in the mice following I/R. Furthermore, significantly increased serum transaminase levels were found in C57 wild-type mice treated with recombinant WISP1 protein, but not found in TLR4 knockout or TRIF knockout mice subjected to liver I/R. Taken together, WISP1 might contribute to hepatic ischemia reperfusion injury in mice and possibly depends on TLR4/TRIF signaling.

Indexed as

Gene Expression RegulationSignal TransductionAdaptor Proteins, Vesicular TransportAnimalsCCN Intercellular Signaling ProteinsLiverMaleMiceMice, KnockoutProto-Oncogene ProteinsReperfusion InjuryToll-Like Receptor 4Adaptor Proteins, Vesicular TransportCCN4 protein, mouseCCN Intercellular Signaling ProteinsProto-Oncogene ProteinsTicam1 protein, mouseTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID26821752
PMCPMC4731767
OpenAlexW2411732646

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.