Evidence map›Paper›PMID 26821313›Full record

ArticleExperimental brain research2016

Stimulation of the ventral tegmental area increased nociceptive thresholds and decreased spinal dorsal horn neuronal activity in rat.

Ai-Ling Li, Jiny E Sibi, Xiaofei Yang, Jung-Chih Chiao, Yuan Bo Peng

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ai-Ling LiDepartment of Psychology, The University of Texas at Arlington, 501 South Nedderman Drive, P. O. Box 19528, Arlington, TX, 76019-0528, USA.
Jiny E SibiDepartment of Psychology, The University of Texas at Arlington, 501 South Nedderman Drive, P. O. Box 19528, Arlington, TX, 76019-0528, USA.
Xiaofei YangDepartment of Electronic Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Jung-Chih ChiaoDepartment of Electrical Engineering, The University of Texas at Arlington, 501 South Nedderman Drive, P. O. Box 19528, Arlington, TX, 76019-0528, USA.
Yuan Bo PengDepartment of Psychology, The University of Texas at Arlington, 501 South Nedderman Drive, P. O. Box 19528, Arlington, TX, 76019-0528, USA. ypeng@uta.edu.
The University of Texas at Arlington · USHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation has been found to be effective in relieving intractable pain. The ventral tegmental area (VTA) plays a role not only in the reward process, but also in the modulation of nociception. Lesions of VTA result in increased pain thresholds and exacerbate pain in several pain models. It is hypothesized that direct activation of VTA will reduce pain experience. In this study, we investigated the effect of direct electrical stimulation of the VTA on mechanical, thermal and carrageenan-induced chemical nociceptive thresholds in Sprague-Dawley rats using our custom-designed wireless stimulator. We found that: (1) VTA stimulation itself did not show any change in mechanical or thermal threshold; and (2) the decreased mechanical and thermal thresholds induced by carrageenan injection in the hind paw contralateral to the stimulation site were significantly reversed by VTA stimulation. To further explore the underlying mechanism of VTA stimulation-induced analgesia, spinal cord dorsal horn neuronal responses to graded mechanical stimuli were recorded. VTA stimulation significantly inhibited dorsal horn neuronal activity in response to pressure and pinch from the paw, but not brush. This indicated that VTA stimulation may have exerted its analgesic effect via descending modulatory pain pathways, possibly through its connections with brain stem structures and cerebral cortex areas.

Indexed as

AnalgesiaAnimalsBehavior, AnimalFemaleNociceptionPain ThresholdPosterior Horn CellsRatsRats, Sprague-DawleyVentral Tegmental AreaAnalgesiaDorsal hornNociceptive thresholdVentral tegmental area

Identifiers

PMID26821313
OpenAlexW2271087016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.