Evidence map›Paper›PMID 26821169›Full record

ArticlePediatric research2016

Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents.

Jeanie L Y Cheong, Alan Bainbridge, Peter J Anderson, Katherine J Lee, Alice C Burnett, Deanne K Thompson, Gehan Roberts, Stephen J Wood, Lex W Doyle, Nicola J Robertson

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Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Reduced prefrontal total choline MRS levels characterize the neurodevelopmental phenotype of bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeanie L Y CheongNeonatal Services, Royal Women's Hospital, Melbourne, Australia.
Alan BainbridgeUniversity College London Hospitals NHS trust, London, UK.
Peter J AndersonVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Katherine J LeeVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Alice C BurnettVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Deanne K ThompsonVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Gehan RobertsVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Stephen J WoodSchool of Psychology, University of Birmingham, Edgbaston, UK.
Lex W DoyleNeonatal Services, Royal Women's Hospital, Melbourne, Australia.
Nicola J RobertsonInstitute for Women's Health, University College London, London, UK.

Funding

Department of Health
6 · The paper itself

Abstract

backgroundExtremely preterm (EP, <28 wk gestation) individuals have increased the risk of cognitive deficits compared with controls. The posterior cingulate region has an important role in cognitive function, but how this is affected by preterm birth is unknown. We aimed to compare brain metabolite ratios of neurons and cell membranes between EP 18-y olds and controls, and explore the association between metabolite ratios and cognitive outcomes.

methodA regional cohort of 150 EP and 134 controls were recruited for the study. Cerebral metabolites were measured using proton magnetic resonance spectroscopy (MRS) obtained from a left posterior cingulate voxel. Total N-acetylaspartate (tNAA, neuronal marker)/total creatine (tCr), and total choline (tCho, cell membrane marker)/tCr ratios were compared between groups using linear regression. Metabolite ratios were correlated with tests of general intelligence (IQ), memory, and attention using linear or logistic regression.

resultsCompared with controls, EP had lower tNAA/tCr (mean difference (95% CI) of -2.27% (-4.09, -0.45)) and tCho/tCr (mean difference (95% CI) of -11.11% (-20.37, -1.85)), all P = 0.02. Higher tCho/tCr correlated with better IQ in the EP group only; whereas higher tNAA/tCr ratios correlated with better scores in working memory and attention in both groups.

conclusionEP birth is associated with long-term brain metabolite ratio alterations. This may underlie poorer cognitive performance in EP survivors.

Indexed as

AdolescentAspartic AcidAustraliaBrainCell MembraneCholineCognitionCognition DisordersCognitive DysfunctionCreatinineFemaleGyrus CinguliHumansInfant, PrematureMagnetic Resonance SpectroscopyMaleAspartic AcidCholineCreatinineN-acetylaspartate

Identifiers

PMID26821169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.