ArticlePloS one2016
A Unidirectional Cell Switching Gate by Engineering Grating Length and Bending Angle.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Enhanced Unidirectional Cell Migration Induced by Asymmetrical Micropatterns with Nanostructures.Journal of functional biomaterials · 2025Article
- Biointerfaces with ultrathin patterns for directional control of cell migration.Journal of nanobiotechnology · 2024Article
- Effects of nanopillars and surface coating on dynamic traction force.Microsystems & nanoengineering · 2023Article
- Engineered barriers regulate osteoblast cell migration in vertical direction.Scientific reports · 2022Article
- Effects of topographical guidance cues on osteoblast cell migration.Scientific reports · 2020Article
- Migration of immortalized nasopharyngeal epithelia and carcinoma cells through porous membrane in 3D platforms.Bioscience reports · 2020Article
- Traversing behavior of tumor cells in three-dimensional platforms with different topography.PloS one · 2020Article
- Cell traction force in a confined microenvironment with double-sided micropost arrays.RSC advances · 2019Article
- Control of neural probe shank flexibility by fluidic pressure in embedded microchannel using PDMS/PI hybrid substrate.PloS one · 2019Article
- Dynamic Tracking of Osteoblastic Cell Traction Force during Guided Migration.Cellular and molecular bioengineering · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On a microgrooved substrate, cells migrate along the pattern, and at random positions, reverse their directions. Here, we demonstrate that these reversals can be controlled by introducing discontinuities to the pattern. On "V-shaped grating patterns", mouse osteogenic progenitor MC3T3-E1 cells reversed predominately at the bends and the ends. The patterns were engineered in a way that the combined effects of angle- and length-dependence could be examined in addition to their individual effects. Results show that when the bend was placed closer to one end, migration behaviour of cells depends on their direction of approach. At an obtuse bend (135°), more cells reversed when approaching from the long segment than from the short segment. But at an acute bend (45°), this relationship was reversed. Based on this anisotropic behaviour, the designed patterns effectively allowed cells to move in one direction but blocked migrations in the opposing direction. This study demonstrates that by the strategic placement of bends and ends on grating patterns, we can engineer effective unidirectional switching gates that can control the movement of adherent cells. The knowledge developed in this study could be utilised in future cell sorting or filtering platforms without the need for chemotaxis or microfluidic control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.