ArticleMolecules (Basel, Switzerland)2016
Metabolite Profiling Reveals the Effect of Dietary Rubus coreanus Vinegar on Ovariectomy-Induced Osteoporosis in a Rat Model.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Investigating the role of Rubus coreanus in enhancing peri-implant bone healing in healthy and estrogen-deficient rats.Scientific reports · 2025Article
- Article
- Dynamics of Physicochemical Properties, Functional Compounds and Antioxidant Capacity during Spontaneous Fermentation ofFoods (Basel, Switzerland) · 2022Article
- Application of metabolomics in osteoporosis research.Frontiers in endocrinology · 2022Review
- A Distinctive Human Metabolomics Alteration Associated with Osteopenic and Osteoporotic Patients.Metabolites · 2021Article
- Metabolomics and physiological analysis of the effect of calcium supplements on reducing bone loss in ovariectomized rats by increasing estradiol levels.Nutrition & metabolism · 2021Article
- Article
- Integrated Network Pharmacology and GC-MS-Based Metabolomics to Investigate the Effect of Xiang-Su Volatile Oil Against Menopausal Depression.Frontiers in pharmacology · 2021Article
- Metabolomics-based profiles predictive of low bone mass in menopausal women.Bone reports · 2018Article
- Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study.International journal of environmental research and public health · 2018Article
- Bioactive Compounds in Cornelian Cherry Vinegars.Molecules (Basel, Switzerland) · 2018Article
- Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses OsteoclastogenesisFrontiers in pharmacology · 2017Article
- Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research.International journal of molecular sciences · 2016Review
- Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats.Journal of nutrition and metabolism · 2016Article
- Anti-osteoporotic Effect ofIranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study was aimed at exploring the curative effects of Rubus coreanus (RC) vinegar against postmenopausal osteoporosis by using ovariectomized rats as a model. The investigations were performed in five groups: sham, ovariectomized (OVX) rats without treatment, low-dose RC vinegar (LRV)-treated OVX rats, high-dose RC vinegar (HRV)-treated OVX rats and alendronate (ALEN)-treated OVX rats. The efficacy of RC vinegar was evaluated using physical, biochemical, histological and metabolomic parameters. Compared to the OVX rats, the LRV and HRV groups showed positive effects on the aforementioned parameters, indicating estrogen regulation. Plasma metabolome analysis of the groups using gas chromatography-time of flight mass spectrometry (GC-TOF-MS) and ultra-performance liquid chromatography quadrupole-TOF-MS (UPLC-Q-TOF-MS) with multivariate analysis revealed 19 and 16 metabolites, respectively. Notably, the levels of butyric acid, phenylalanine, glucose, tryptophan and some lysophosphatidylcholines were marginally increased in RC vinegar-treated groups compared to OVX. However, the pattern of metabolite levels in RC vinegar-treated groups was found similar to ALEN, but differed significantly from that in sham group. The results highlight the prophylactic and curative potential of dietary vinegar against postmenopausal osteoporosis. RC vinegar could be an effective natural alternative for the prevention of postmenopausal osteoporosis.
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