Evidence map›Paper›PMID 26820883›Full record

ArticlePloS one2016

Ultrasound Evaluation of the Combined Effects of Thoracolumbar Fascia Injury and Movement Restriction in a Porcine Model.

James H Bishop, James R Fox, Rhonda Maple, Caitlin Loretan, Gary J Badger, Sharon M Henry, Margaret A Vizzard, Helene M Langevin

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Morphological characteristics of the thoracolumbar fascia: relationship to chronic low back pain and back extension strength.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  9. Fascial Nodal PointMedical acupuncture · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

James H BishopDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, United States of America.
James R FoxDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, United States of America.
Rhonda MapleDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, United States of America.
Caitlin LoretanDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, United States of America.
Gary J BadgerDepartment of Medical Biostatistics, University of Vermont, Burlington, Vermont, United States of America.
Sharon M HenryDepartment of Rehabilitation and Movement Science, University of Vermont, Burlington, Vermont, United States of America.
Margaret A VizzardDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, United States of America.
Helene M LangevinDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, United States of America.
University of Vermont · USHarvard University · USUniversity of Vermont Medical Center · US

Funding

Cystitis-Induced Plasticity of Micturition ReflexesR01DK051369 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI VIZZARD, MARGARET ANN · 2003 to 2017
$5.4M
Developmental Plasticity of Micturition ReflexesR01DK060481 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI VIZZARD, MARGARET ANN · 2002 to 2018
$4.5M
Connective tissue and nervous system mechanisms of CAM therapies for low back paiR01AT004400 · NCCIH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LANGEVIN, HELENE M · 2011 to 2015
$1.9M
NCCIH NIH HHS R01 AT004400NCCIH NIH HHS R01AT004400NIDDK NIH HHS R01 DK051369NIDDK NIH HHS R01 DK060481
6 · The paper itself

Abstract

The persistence of back pain following acute back "sprains" is a serious public health problem with poorly understood pathophysiology. The recent finding that human subjects with chronic low back pain (LBP) have increased thickness and decreased mobility of the thoracolumbar fascia measured with ultrasound suggest that the fasciae of the back may be involved in LBP pathophysiology. This study used a porcine model to test the hypothesis that similar ultrasound findings can be produced experimentally in a porcine model by combining a local injury of fascia with movement restriction using a "hobble" device linking one foot to a chest harness for 8 weeks. Ultrasound measurements of thoracolumbar fascia thickness and shear plane mobility (shear strain) during passive hip flexion were made at the 8 week time point on the non-intervention side (injury and/or hobble). Injury alone caused both an increase in fascia thickness (p = .007) and a decrease in fascia shear strain on the non-injured side (p = .027). Movement restriction alone did not change fascia thickness but did decrease shear strain on the non-hobble side (p = .024). The combination of injury plus movement restriction had additive effects on reducing fascia mobility with a 52% reduction in shear strain compared with controls and a 28% reduction compared to movement restriction alone. These results suggest that a back injury involving fascia, even when healed, can affect the relative mobility of fascia layers away from the injured area, especially when movement is also restricted.

Indexed as

AnimalsCalcitonin Gene-Related PeptideFasciaGaitLow Back PainMaleRange of Motion, ArticularSpinal CordSubstance PSus scrofaUltrasonographyCalcitonin Gene-Related PeptideSubstance P

Identifiers

PMID26820883
PMCPMC4731465
OpenAlexW2254821437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.