Trial reportFertility and sterility2016
Prospective evaluation of the impact of intermenstrual bleeding on natural fertility.
Trial report in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01028365 (Time to Conceive), which is not on this map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Time to Conceive: A Study of Fertility: Biomarkers of Fertility
Who cites it
6 citing papers in PubMed.
- Menstrual cycle characteristics as an indicator of fertility outcomes: evidence from prospective birth cohort study in China.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Clinical Manifestations of Polycystic Ovary Syndrome and Associations With the Vaginal Microbiome: A Cross-Sectional Based Exploratory Study.Frontiers in endocrinology · 2021Article
- Challenges and future directions in menstrual cycle research.Paediatric and perinatal epidemiology · 2020Article
- Pre-conception 25-hydroxyvitamin D (25(OH)D) and fecundability.Human reproduction (Oxford, England) · 2019Article
- 25-Hydroxyvitamin D and Long Menstrual Cycles in a Prospective Cohort Study.Epidemiology (Cambridge, Mass.) · 2018Article
- Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters.BMC genomics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveTo evaluate the impact of an episode of intermenstrual bleeding on the probability of conception in a menstrual cycle (fecundability).
designProspective, time-to-pregnancy cohort study.
settingCommunity-based cohort. PATIENT(S): Women trying to conceive, ages 30 to 44 years, without known infertility. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): Current cycle and subsequent cycle fecundability. RESULT(S): A total of 549 women provided 1,552 complete cycles for analysis. Intermenstrual and luteal bleeding were reported in 36% and 34% of cycles, respectively. Ninety-three percent of all intermenstrual bleeding was luteal. Cycles in which women had intermenstrual bleeding or luteal bleeding were statistically significantly less likely to result in conception (fecundability ratio [FR] 0.23; 95% confidence interval [CI], 0.16-0.34; and FR 0.22; 95% CI, 0.14-0.33). Women with an episode of intermenstrual and luteal bleeding had a statistically significant increase in the probability of pregnancy in the subsequent cycle (FR 1.61; 95% CI, 1.15-2.25; and FR 2.01; 95% CI, 1.52-2.87, respectively). CONCLUSION(S): Intermenstrual bleeding statistically significantly decreases the odds of conceiving in that cycle but does not appear to negatively impact a woman's immediate future reproductive potential. CLINICAL TRIAL REGISTRATION NUMBER: NCT01028365.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.