ReviewInternational orthopaedics2016
Overview: the role of Propionibacterium acnes in nonpyogenic intervertebral discs.
Review in International orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Evidence for infection in intervertebral disc degeneration: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Pooled it
- Article
- Hydrogels Targeting Mechanical-biological signaling transitions of interleukin-33 alleviates intervertebral-disc degeneration.Materials today. Bio · 2026Article
- Intervertebral disc puncture predisposes the disc to Cutibacterium acnes infection via hematogenous and contiguous routes: a rat model study.Journal of orthopaedic surgery and research · 2026Article
- 2bRAD-M reveals differences in microbial communities between Modic changes and disc herniation.Frontiers in cellular and infection microbiology · 2025Article
- The safety and effectiveness of transforaminal lumbar interbody fusion (TLIF) surgery for the treatment of lumbar disc herniation.Frontiers in surgery · 2025Article
- Does hydrogen peroxide help mitigate the incidence ofNorth American Spine Society journal · 2024Article
- Pyroptosis in Skeleton Diseases: A Potential Therapeutic Target Based on Inflammatory Cell Death.International journal of molecular sciences · 2024Review
- Causal effects of skin microbiota on intervertebral disk degeneration, low back pain and sciatica: a two-sample Mendelian randomization study.Journal of orthopaedic surgery and research · 2024Article
- Efficacy of stepped care treatment for chronic discogenic low back pain patients with Modic I and II changes.Interventional pain medicine · 2023Article
- Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.Molecular biology reports · 2023Article
- Role of Pyroptosis in Intervertebral Disc Degeneration and Its Therapeutic Implications.Biomolecules · 2022Review
- G-Protein Coupled Receptor 35 Induces Intervertebral Disc Degeneration by Mediating the Influx of Calcium Ions and Upregulating Reactive Oxygen Species.Oxidative medicine and cellular longevity · 2022Article
- Development and validation of a nomogram predicting the risk of recurrent lumbar disk herniation within 6 months after percutaneous endoscopic lumbar discectomy.Journal of orthopaedic surgery and research · 2021Article
- A Janus-Faced Bacterium: Host-Beneficial and -Detrimental Roles ofFrontiers in microbiology · 2021Review
- The Role ofBiomedicines · 2020Article
- Higher proportion of low-virulence anaerobic bacterial infection in young patients with intervertebral disc herniation.Experimental and therapeutic medicine · 2019Article
- Current concepts for lumbar disc herniation.International orthopaedics · 2019Review
- Propionibacterium acnes induces discogenic low back pain via stimulating nucleus pulposus cells to secrete pro-algesic factor of IL-8/CINC-1 through TLR2-NF-κB p65 pathway.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Latent infection of low-virulence anaerobic bacteria in degenerated lumbar intervertebral discs.BMC musculoskeletal disorders · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propionibacterium acnes (P. acnes), an important opportunistic anaerobic Gram-positive bacterium, causes bone and joint infections, discitis and spondylodiscitis. Accumulated evidence suggested that this microbe can colonise inside intervertebral discs without causing symptoms of discitis. Epidemiological investigation shows that the prevalence ranges from 13 % to 44 %. Furthermore, colonisation by P. acnes inside nonpyogenic intervertebral discs is thought to be one pathogen causing sciatica, Modic changes and nonspecific low back pain. Specially, patients can attain significant relief of low back pain, amelioration of Modic changes and alleviation of sciatica after antibiotic therapy, indicating the role of P. acnes in these pathological changes. However, until now, there were hypotheses only to explain problems such as how P. acnes access intervertebral discs and what the exact pathological mechanism it employs during its latent infection period. In addition, research regarding diagnostic procedures and treatment strategies were also rare. Overall, the prevalence and possible pathological role that P. acnes plays inside nonpyogenic intervertebral discs is summarised in this paper.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.