ArticleInternational journal of clinical oncology2016
Colorectal cancer in young patients: is it a distinct clinical entity?
Article in International journal of clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A comparison of overall survival from early-onset and late-onset colorectal cancer stratified by TNM stage: a systematic review.British journal of cancer · 2026Pooled it
- Development and validation of a nomogram to predict overall survival in young non-metastatic rectal cancer patients after curative resection: a population-based analysis.International journal of colorectal disease · 2022Trial
- Universal Tumor Screening in Colorectal Cancer: Role of MMR Immunohistochemistry for Lynch Syndrome and Early-Onset CRC.Cancers · 2026Article
- Adenocarcinoma of the colon in a pediatric patient: a rare case report.Journal of surgical case reports · 2026Article
- Impact of age and rurality on colorectal cancer outcomes in the United States.Cancer causes & control : CCC · 2026Article
- Article
- Risk of Advanced Adenomas in Siblings Aged ≤ 50 Years of Patients with Early-Onset Colorectal Advanced Adenomas.Digestive diseases and sciences · 2025Article
- Early-Onset Colorectal Cancer: From Genetic Discovery to Clinical Innovation.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2025Review
- Genetic and transcriptomic analyses of early-onset colon cancer (EOCC): aESMO gastrointestinal oncology · 2025Article
- Early onset metastatic colorectal cancer patients as a distinctive clinical and molecular phenomenon.British journal of cancer · 2025Article
- Trends, global comparisons, and projections of early onset colorectal cancer burden in China based on GBD study 2021.Scientific reports · 2025Article
- Characteristics, Treatment and Outcomes of Stage I to III Colorectal Cancer in Patients Aged over 80 Years Old.Cancers · 2025Article
- A Survey Detailing Early Onset Colorectal Cancer Patient and Caregiver Experiences in Canada.Current oncology (Toronto, Ont.) · 2024Article
- Age-related differences in progression patterns, follow-up strategies, and postoperative outcomes in locally advanced rectal cancer: insights from a large-scale validated study.Therapeutic advances in medical oncology · 2024Article
- Early-Onset Colon Cancer: A Narrative Review of Its Pathogenesis, Clinical Presentation, Treatment, and Prognosis.Cureus · 2023Review
- Early-Onset Colorectal Cancer: Current Insights.Cancers · 2023Review
- A Retrospective Multicenter Study of the Clinicopathological Characteristics and Prognosis of Young Adult Patients with Colorectal Cancer: Effects of Chemotherapy on Prognosis.Journal of clinical medicine · 2023Article
- Early-onset colorectal cancer: A review of current knowledge.World journal of gastroenterology · 2023Review
- Clinicopathological and molecular characteristics of early-onset vs late-onset colorectal cancer according to tumor location.International journal of clinical oncology · 2022Article
- Clinicopathological patterns and survival outcomes of colorectal cancer among young adults in Malaysia: an institutional cohort study.Singapore medical journal · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of colorectal cancer in young patients is increasing. It remains unclear if the disease has unique features in this age group.
methodsThis was a single-center, retrospective cohort study which included patients diagnosed with colorectal cancer at age ≤40 years in 1997-2013 matched 1:2 by year of diagnosis with consecutive colorectal cancer patients diagnosed at age >50 years during the same period. Patients aged 41-50 years were not included in the study, to accentuate potential age-related differences. Clinicopathological characteristics, treatment, and outcome were compared between groups.
resultsThe cohort included 330 patients, followed for a median time of 65.9 months (range 4.7-211). Several significant differences were noted. The younger group had a different ethnic composition. They had higher rates of family history of colorectal cancer (p = 0.003), hereditary colorectal cancer syndromes (p < 0.0001), and inflammatory bowel disease (p = 0.007), and a lower rate of polyps (p < 0.0001). They were more likely to present with stage III or IV disease (p = 0.001), angiolymphatic invasion, signet cell ring adenocarcinoma, and rectal tumors (p = 0.02). Younger patients more frequently received treatment. Young patients had a worse estimated 5-year disease-free survival rate (57.6 vs. 70 %, p = 0.039), but this did not retain significance when analyzed by stage (p = 0.092). Estimated 5-year overall survival rates were 59.1 and 62.1 % in the younger and the control group, respectively (p = 0.565).
conclusionsColorectal cancer among young patients may constitute a distinct clinical entity. Further research is needed to validate our findings and define the optimal approach in this population.
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