SynthesisPloS one2016
Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Value of intravoxel incoherent motion in detecting and staging liver fibrosis: A meta-analysis.World journal of gastroenterology · 2020Pooled it
- Diffusion-weighted imaging for staging chronic kidney disease: a meta-analysis.The British journal of radiology · 2018Pooled it
- Diffusion-Weighted Imaging-Based Virtual MR Elastography of the Liver: Beyond Mechanical Waves.Korean journal of radiology · 2026Review
- Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers.Magnetic resonance in medicine · 2026Article
- Optimized acquisition for simultaneous intravoxel incoherent motion and RMagnetic resonance in medicine · 2025Article
- Predictive intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters in the staging of fibrosis in hepatitis B patients.Polish journal of radiology · 2025Article
- Reproducibility of intravoxel incoherent motion quantification in the liver across field strengths and gradient hardware.Magnetic resonance in medicine · 2024Article
- Multiparametric MRI combined with liver volume for quantitative evaluation of liver function in patients with cirrhosis.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Article
- b value and first-order motion moment optimized data acquisition for repeatable quantitative intravoxel incoherent motion DWI.Magnetic resonance in medicine · 2022Article
- Intravoxel incoherent motion diffusion-weighted MRI for the characterization of inflammation in chronic liver disease.European radiology · 2021Article
- Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats.Scientific reports · 2020Article
- Metabolic Changes in Different Stages of Liver Fibrosis: In vivo HyperpolarizedMolecular imaging and biology · 2019Article
- Putting it all together: established and emerging MRI techniques for detecting and measuring liver fibrosis.Pediatric radiology · 2018Review
- Evaluation of liver fibrosis with a monoexponential model of intravoxel incoherent motion magnetic resonance imaging.Oncotarget · 2018Article
- Using IVIM-MRI and R2⁎ Mapping to Differentiate Early Stage Liver Fibrosis in a Rat Model of Radiation-Induced Liver Fibrosis.BioMed research international · 2018Article
- Diffusion weighted magnetic resonance imaging of liver: Principles, clinical applications and recent updates.World journal of hepatology · 2017Review
- Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel.Abdominal radiology (New York) · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the potential of intravoxel incoherent motion (IVIM) MR imaging for staging of hepatic fibrosis (HF).
methodsWe searched PubMed and EMBASE from their inception to 31 July 2015 to select studies reporting IVIM MR imaging and HF staging. We defined F1-2 as non-advanced HF, F3-4 as advanced HF, F0 as normal liver, F1 as very early HF, and F2-4 as significant HF. Then we compared stage F0 with F1, F0-1 with F2-3, and F1-2 with F3-4 using IVIM-derived parameters (pseudo-diffusion coefficient D*, perfusion fraction f, and pure molecular diffusion parameter D). The effect estimate was expressed as a pooled weighted mean difference (WMD) with 95% confidence interval (CI), using the fixed-effects model.
resultsOverall, we included six papers (406 patients) in this study. Significant differences in D* were observed between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 2.46, 95% CI 0.83-4.09, P = 0.006; WMD 13.10, 95% CI 9.53-16.67, P < 0.001; WMD 14.34, 95% CI 10.26-18.42, P < 0.001, respectively). Significant differences in f were also found between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 1.62, 95% CI 0.06-3.18, P = 0.027; WMD 5.63, 95% CI 2.74-8.52, P < 0.001; WMD 3.30, 95% CI 2.10-4.50, P < 0.001, respectively). However, D showed no differences between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 0.05, 95% CI -0.01─0.11, P = 0.105; WMD 0.04, 95% CI -0.01─0.10, P = 0.230; WMD 0.02, 95% CI -0.02─0.06, P = 0.378, respectively).
conclusionsIVIM MR imaging provides an effective method of staging HF and can distinguish early HF from normal liver, significant HF from normal liver or very early HF, and advanced HF from non-advanced HF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.