SynthesisJournal of autism and developmental disorders2016
Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis.
Synthesis in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Review
- Glucose and Oxygen Metabolism Coordinate Human Cortical Developmental Decisions.bioRxiv : the preprint server for biology · 2025Article
- Brief Report: Atypical Temporal Sensitivity in Coarticulation in Autism: Evidence from Sibilant-Vowel Interaction in Cantonese.Journal of autism and developmental disorders · 2025Article
- Perinatal adversities as a common factor underlying the association between atypical laterality and neurodevelopmental disorders: A developmental perspective.Psychophysiology · 2024Review
- Raloxifene Protects Oxygen-Glucose-Deprived Astrocyte Cells Used to Mimic Hypoxic-Ischemic Brain Injury.International journal of molecular sciences · 2024Article
- Neonatal risk factors associated with autism spectrum disorders: an umbrella review.Clinical and experimental pediatrics · 2024Article
- Evaluation of Individuals with Non-Syndromic Global Developmental Delay and Intellectual Disability.Children (Basel, Switzerland) · 2023Review
- Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study.Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia.Epilepsia · 2021Article
- Prenatal and perinatal metabolic risk factors for autism: a review and integration of findings from population-based studies.Current opinion in psychiatry · 2021Review
- In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring.JCI insight · 2020Article
- Autism spectrum disorder.Nature reviews. Disease primers · 2020Review
- Apgar score and risk of autism.European journal of epidemiology · 2019Article
- The Apgar paradox.European journal of epidemiology · 2019Article
- Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal Asphyxia.Frontiers in neuroscience · 2019Article
- Autism Spectrum Disorders and Perinatal Complications-Is Oxidative Stress the Connection?Frontiers in psychiatry · 2019Article
- Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months.Pediatric research · 2018Observational
- Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses.Molecular autism · 2017Review
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted meta-analyses of 67 studies on the association between neonatal proxies of impaired gas exchange and intellectual disability (ID) or autism spectrum disorders (ASD). Neonatal acidosis was associated with an odds ratio (OR) of 3.55 [95 % confidence interval (95 % CI) 2.23-5.49] for ID and an OR of 1.10 (95 % CI 0.91-1.31) for ASD. Children with a 5-min Apgar score of <7 had an OR of 5.39 (95 % CI 3.84-7.55) for ID and an OR of 1.67 (95 % CI 1.34-2.09) for ASD. O2 treatment was associated with an OR of 4.32 (95 % CI 3.23-5.78) for ID and an OR of 2.02 (95 % CI 1.45 to 2.83) for ASD. Our meta-analysis demonstrates an increased risk of ID and (to a lesser extent) ASD in children with neonatal hypoxia. Moreover, our findings raise the possibility that concomitant ID might account for the observed association between the gas exchange proxies and ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.