Evidence map›Paper›PMID 26820589›Full record

ArticleBehavioral neuroscience2016

Sleep quality and depressive symptoms after prostate cancer: The mechanistic role of cortisol.

Michael A Hoyt, Julienne E Bower, Michael R Irwin, Mariann R Weierich, Annette L Stanton

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  14. Problems sleeping with prostate cancer: exploring possible risk factors for sleep disturbance in a population-based sample of survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Article
  15. Article
  16. Impact of lifestyle in prostate cancer patients. What should we do?International braz j urol : official journal of the Brazilian Society of Urology
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Michael A HoytDepartment of Psychology, Graduate Center, Hunter College, City University of New York.
Julienne E BowerDepartment of Psychology, Cousins Center for Psychoneuroimmunology, Semel Institute, University of California, Los Angeles.
Michael R IrwinDepartment of Psychology, Cousins Center for Psychoneuroimmunology, Semel Institute, University of California, Los Angeles.
Mariann R WeierichDepartment of Psychology, Graduate Center, Hunter College, City University of New York.
Annette L StantonDepartment of Psychology, Cousins Center for Psychoneuroimmunology, Semel Institute, University of California, Los Angeles.
The Graduate Center, CUNY · USUniversity of California, Los Angeles · USInstitute of Neuroimmunology of the Slovak Academy of Sciences · SK

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Emotion-Regulation, Inflammatory Processes, and Depression in Prostate Cancer SurSC1CA187494 · NCI · HUNTER COLLEGE · PI HOYT, MICHAEL A · 2014 to 2017
$1.6M
NCI NIH HHS L30 CA136998NCI NIH HHS SC1 CA187494NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

A substantial portion of men treated for prostate cancer report clinically significant sleep problems and disturbance in sleep quality constitutes significant risk for the development of depressive symptoms in survivors. Dysregulation in biological stress processes underlies the impact of poor sleep on the onset and/or progression of depressive symptoms, yet few studies have sought to identify potential neurobiological mechanisms (e.g., HPA axis activation) underlying this association in PC survivors. The present study examines the relationships between sleep disturbance, depressive symptoms, and indices of diurnal cortisol patterns among men treated for prostate cancer. In total, 66 men (84.8% White; mean age = 65.8 years, SD = 9.04) treated in the prior 2 years for localized prostate cancer were recruited. They completed questionnaires to measure sleep quality and depressive symptoms at study entry (T1) and 4 months later (T2). They also provided 4 saliva samples per day, over 3 days, at T1. Three cortisol indices were computed: diurnal slope, area under the curve (AUCg), and cortisol awakening response (CAR). Analyses indicate that, controlling for body mass index and age, worse sleep quality at T1 was significantly associated with higher levels of depressive symptoms at T2. Significant indirect effects were observed for cortisol slope (indirect effect = -.17, 95% CI [-.61, -.01]) and AUCg (indirect effect = -.14, 95% CI [-.43, -.01]), but not CAR. Results suggest that dysregulation in HPA activity acts as a neurobiological mechanism of the impact of sleep disruption on depressive symptoms in men with prostate cancer. (PsycINFO Database Record

Indexed as

Sleep Initiation and Maintenance DisordersAgedCircadian RhythmDepressionHumansHydrocortisoneMaleProstatic NeoplasmsSurveys and QuestionnairesHydrocortisone

Identifiers

PMID26820589
PMCPMC4877249
OpenAlexW2397395737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.