ArticlePloS one2016
Specific Gene Loci of Clinical Pseudomonas putida Isolates.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Beyond the Usual Suspects: EmergingInternational journal of molecular sciences · 2026Review
- Unraveling the genomic diversity of the Pseudomonas putida group: exploring taxonomy, core pangenome, and antibiotic resistance mechanisms.FEMS microbiology reviews · 2024Review
- Identification and florfenicol-treatment of pseudomonas putida infection in gilthead seabream (Sparus aurata) fed on tilapia-trash-feed.BMC veterinary research · 2024Article
- Pseudomonas putida infection induces immune-antioxidant, hepato-renal, ethological, and histopathological/immunohistochemical disruptions in Oreochromis niloticus: the palliative role of titanium dioxide nanogel.BMC veterinary research · 2024Article
- Toxin-antitoxin systems in bacterial pathogenesis.Heliyon · 2023Review
- Transcriptional organization and regulation of theMicrobiology (Reading, England) · 2023Article
- Clinical features, risk factors, and antimicrobial resistance of pseudomonas putida isolates.Medicine · 2022Observational
- Insertion sequences and other mobile elements associated with antibiotic resistance genes inMicrobial genomics · 2022Article
- Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat.International journal of molecular sciences · 2021Review
- Risk factors and antimicrobial resistance profiles of Pseudomonas putida infection in Central China, 2010-2017.Medicine · 2019Observational
- A multilocus sequence typing scheme of Pseudomonas putida for clinical and environmental isolates.Scientific reports · 2019Article
- Genome Sequence Analysis of Two Pseudomonas putida Strains to Identify a 17-Hydroxylase Putatively Involved in Sparteine Degradation.Current microbiology · 2018Article
- Diversity, Prevalence, and Longitudinal Occurrence of Type II Toxin-Antitoxin Systems ofFrontiers in microbiology · 2017Article
- Emerging Roles of Toxin-Antitoxin Modules in Bacterial Pathogenesis.Molecules (Basel, Switzerland) · 2016Review
- Iron Uptake Analysis in a Set of Clinical Isolates ofFrontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas putida are ubiquitous inhabitants of soils and clinical isolates of this species have been seldom described. Clinical isolates show significant variability in their ability to cause damage to hosts because some of them are able to modulate the host's immune response. In the current study, comparisons between the genomes of different clinical and environmental strains of P. putida were done to identify genetic clusters shared by clinical isolates that are not present in environmental isolates. We show that in clinical strains specific genes are mostly present on transposons, and that this set of genes exhibit high identity with genes found in pathogens and opportunistic pathogens. The set of genes prevalent in P. putida clinical isolates, and absent in environmental isolates, are related with survival under oxidative stress conditions, resistance against biocides, amino acid metabolism and toxin/antitoxin (TA) systems. This set of functions have influence in colonization and survival within human tissues, since they avoid host immune response or enhance stress resistance. An in depth bioinformatic analysis was also carried out to identify genetic clusters that are exclusive to each of the clinical isolates and that correlate with phenotypical differences between them, a secretion system type III-like was found in one of these clinical strains, a determinant of pathogenicity in Gram-negative bacteria.
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