ArticleNeuroradiology2016
The plasticity of intrinsic functional connectivity patterns associated with rehabilitation intervention in chronic stroke patients.
Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Disruptions of resting-state functional connectivity in post-stroke motor dysfunctions: a meta-analysis.Brain imaging and behavior · 2025Pooled it
- A systematic review: enhancing stroke recovery through complementary interventions-Clinical outcomes and neural activity insights.Frontiers in neuroscience · 2024Pooled it
- MRI markers of functional connectivity and tissue microstructure in stroke-related motor rehabilitation: A systematic review.NeuroImage. Clinical · 2022Pooled it
- Visuomotor training induces network reorganisation of frontal eye field and cuneus connectivity: A task-based fMRI study.Neuroimage. Reports · 2026Article
- Source-Level Resting-State EEG Connectivity Reveals Frequency-Specific Neural Reorganization and Predicts Motor Recovery in Individuals Post Stroke Following Gait Rehabilitation.Research square · 2025Article
- Alterations of static and dynamic changes in intrinsic brain activity and its relation to behavioral outcomes in subcortical ischemic stroke after one-month intervention.Scientific reports · 2025Article
- Resting-State Cortico-Cerebellar Connectivity Correlates with Post-Stroke Motor Recovery - A Prospective Functional MRI Study.Cerebellum (London, England) · 2025Article
- Advanced rehabilitation in ischaemic stroke research.Stroke and vascular neurology · 2024Review
- Recovered grasping performance after stroke depends on interhemispheric frontoparietal connectivity.Brain : a journal of neurology · 2023Article
- Pathway-Specific Mediation Effect Between Structure, Function, and Motor Impairment After Subcortical Stroke.Neurology · 2023Article
- Article
- Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack.Neural plasticity · 2022Article
- Neuroplasticity after upper-extremity rehabilitation therapy with sensory stimulation in chronic stroke survivors.Brain communications · 2022Article
- Ability of an altered functional coupling between resting-state networks to predict behavioral outcomes in subcortical ischemic stroke: A longitudinal study.Frontiers in aging neuroscience · 2022Article
- Test-retest reliability of peak location in the sensorimotor network of resting state fMRI for potential rTMS targets.Frontiers in neuroinformatics · 2022Article
- Aberrant interhemispheric functional reciprocities of the default mode network and motor network in subcortical ischemic stroke patients with motor impairment: A longitudinal study.Frontiers in neurology · 2022Article
- Early motor network connectivity after stroke: An interplay of general reorganization and state-specific compensation.Human brain mapping · 2021Article
- The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches.Neural regeneration research · 2021Article
- Changes in Cortical Activity in Stroke Survivors Undergoing Botulinum Neurotoxin Therapy for Treatment of Focal Spasticity.Frontiers in rehabilitation sciences · 2021Article
- Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors.Neural plasticity · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIt has been demonstrated that rehabilitative interventions can promote motor function recovery in stroke patients. However, little is known regarding the neural mechanisms that underlie the rehabilitation treatments. The aim of this study was to investigate the plasticity of intrinsic functional connectivity patterns that are associated with rehabilitation intervention in chronic stroke patients.
methodsTwelve chronic stroke patients with subcortical lesions in the left motor pathway participated in a 4-week rehabilitation intervention and underwent resting-state functional magnetic resonance imaging (fMRI) scanning before and after the intervention. Both functional connectivity analyses of the ipsilesional (left) primary motor cortex (M1) and measurements of the lateralization index of the connectivity patterns were performed in both the stroke patients and healthy controls (HC).
resultsCompared with the HC, the decreased connectivity of the ipsilesional M1 with the contralesional sensorimotor cortex (SMC), bilateral supplementary motor areas, and inferior parietal lobule due to stroke were remarkably restored after the intervention. More specifically, the lateralization index of the bilateral SMC tends to be the normal level. Moreover, comparing post- with pre-intervention, we observed significantly increased connectivity of ipsilesional M1 with the contralesional M1 and medial superior frontal gyrus (mSFG). Additionally, the index of pre-intervention connectivity with the contralesional mSFG was positively correlated with motor improvement.
conclusionThe impact of rehabilitation intervention on intrinsic functional connectivity patterns throughout the brain was measurable on resting-state fMRI, and systematic assessment of resting-state functional connectivity can provide prognostic insight for later motor improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.