Evidence map›Paper›PMID 26820411›Full record

ReviewTransgenic research2016

Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts.

Jun Wu, Juan Carlos Izpisua Belmonte

Abstract readReview
PubMed Publisher
In one paragraph

Review in Transgenic research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Modelling the endocrine pancreas in health and disease.Nature reviews. Endocrinology · 2019
    Review
  5. Article
  6. Article
  7. Synthetic Biology in Cell and Organ Transplantation.Cold Spring Harbor perspectives in biology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jun WuGene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA, 92037, USA. Junwu@salk.edu.
Juan Carlos Izpisua BelmonteGene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA, 92037, USA. Belmonte@salk.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The past decade's rapid progress in human pluripotent stem cell (hPSC) research has generated hope for meeting the rising demand of organ donation, which remains the only effective cure for end-stage organ failure, a major cause of death worldwide. Despite the potential, generation of transplantable organs from hPSCs using in vitro differentiation is far-fetched. An in vivo interspecies chimeric complementation strategy relying on chimeric-competent hPSCs and zygote genome editing provides an auspicious alternative for providing unlimited organ source for transplantation.

Indexed as

AnimalsAnimals, Genetically ModifiedBlastocystCell DifferentiationChimeraGenetic EngineeringHumansOrgan TransplantationPluripotent Stem CellsStem Cell ResearchTransplantation, HeterologousBlastocyst complementationInterspecies chimeraIn vivo genome editingiPSCsOrgan transplantationPluripotent stem cells

Identifiers

PMID26820411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.