Evidence map›Paper›PMID 26820362›Full record

ArticleInternational journal of cardiology2016

Mechanisms underlying atrial-selective block of sodium channels by Wenxin Keli: Experimental and theoretical analysis.

Dan Hu, Hector Barajas-Martínez, Alexander Burashnikov, Brian K Panama, Jonathan M Cordeiro, Charles Antzelevitch

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  7. Article
  8. Advances in basic and translational research in atrial fibrillation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
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  19. Application of Traditional Chinese Medicine in Treatment of Atrial Fibrillation.Evidence-based complementary and alternative medicine : eCAM · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dan HuMasonic Medical Research Laboratory, Utica, NY, United States.
Hector Barajas-MartínezMasonic Medical Research Laboratory, Utica, NY, United States.
Alexander BurashnikovLankenau Institute for Medical Research, Wynnewood, PA, United States.
Brian K PanamaMasonic Medical Research Laboratory, Utica, NY, United States.
Jonathan M CordeiroMasonic Medical Research Laboratory, Utica, NY, United States.
Charles AntzelevitchLankenau Institute for Medical Research, Wynnewood, PA, United States. Electronic address: cantzelevitch@gmail.com.
Masonic Medical Research Laboratory · USLankenau Institute for Medical Research · US

Funding

ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIASR01HL047678 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI ANTZELEVITCH, CHARLES · 1993 to 2014
$5.7M
NHLBI NIH HHS R01 HL047678
6 · The paper itself

Abstract

introductionAtrial-selective inhibition of cardiac sodium channel current (INa) and INa-dependent parameters has been shown to contribute to the safe and effective management of atrial fibrillation. The present study was designed to examine the basis for the atrial-selective actions of Wenxin Keli.

methodsWhole cell INa was recorded at room temperature in canine atrial and ventricular myocytes. Trains of 40 pulses were elicited over a range of pulse durations and interpulse intervals to determine tonic and use-dependent block. A Markovian model for INa that incorporates interaction of Wenxin Keli with different states of the channel was developed to examine the basis for atrial selectivity of the drug.

resultsOur data indicate that Wenxin Keli does not bind significantly to either closed or open states of the sodium channel, but binds very rapidly to the inactivated state of the channel and dissociates rapidly from the closed state. Action potentials recorded from atrial and ventricular preparations in the presence of 5g/L Wenxin Keli were introduced into the computer model in current clamp mode to simulate the effects on maximum upstroke velocity (Vmax). The model predicted much greater inhibition of Vmax in atrial vs. ventricular cells at rapid stimulation rates.

conclusionOur findings suggest that atrial selectivity of Wenxin Keli to block INa is due to more negative steady-state inactivation, less negative resting membrane potential, and shorter diastolic intervals in atrial vs. ventricular cells at rapid activation rates. These actions of Wenxin Keli account for its relatively safe and effective suppression of atrial fibrillation.

Indexed as

Models, TheoreticalAction PotentialsAnimalsCells, CulturedDogsDrugs, Chinese HerbalHeart AtriaHeart RateHEK293 CellsHumansMyocytes, CardiacSodium Channel BlockersSodium ChannelsDrugs, Chinese HerbalSodium Channel BlockersSodium Channelswenxin keliAntiarrhythmic drugsArrhythmiasAtriaElectrophysiologyPharmacologyVentricles

Identifiers

PMID26820362
PMCPMC4758862
OpenAlexW2223100915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.