ArticlePlant molecular biology2016
Functional analysis of three BrMYB28 transcription factors controlling the biosynthesis of glucosinolates in Brassica rapa.
Article in Plant molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 50 citations in OpenAlex.
- Application of Metabolomics in Defence Responses ofMetabolites · 2026Review
- Insights into the functions of MYB29 and MYB28.1 involved in glucosinolate biosynthesis from Isatis indigotica Fort.Functional & integrative genomics · 2026Article
- Genetic dissection of low-sulfur tolerance via linkage and genome-wide association analyses in soybean [Glycine max (L.) Merr.] seedlings.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Deciphering the heterogeneous glucosinolates composition in leaves and seeds: strategies for developing Brassica napus genotypes with low seed glucosinolates content but high leaf glucosinolates content.Molecular horticulture · 2025Article
- Structure, evolution, and roles of MYB transcription factors proteins in secondary metabolite biosynthetic pathways and abiotic stresses responses in plants: a comprehensive review.Frontiers in plant science · 2025Review
- A naturally occurring promoter variation ofFrontiers in plant science · 2025Article
- Identifying potential anthocyanin biosynthesis regulator in Chinese cherry by comprehensive genome-wide characterization of the R2R3-MYB transcription factor gene family.BMC genomics · 2024Article
- Blue Light Enhances Health-Promoting Sulforaphane Accumulation in Broccoli (Plants (Basel, Switzerland) · 2023Article
- Developing multifunctional crops by engineering Brassicaceae glucosinolate pathways.Plant communications · 2023Review
- Glucosinolates and Biotic Stress Tolerance in Brassicaceae with Emphasis on Cabbage: A Review.Biochemical genetics · 2023Review
- Natural variation and artificial selection at the BnaC2.MYB28 locus modulate Brassica napus seed glucosinolate.Plant physiology · 2023Article
- Anticancer Effects of High Glucosinolate Synthesis Lines ofAntioxidants (Basel, Switzerland) · 2022Article
- A Comparative Transcriptome and Metabolome Combined Analysis Reveals the Key Genes and Their Regulatory Model Responsible for Glucoraphasatin Accumulation in Radish Fleshy Taproots.International journal of molecular sciences · 2022Article
- Genome-Wide Comparative Analysis of theInternational journal of molecular sciences · 2022Article
- Characterisation of the Introgression ofFrontiers in plant science · 2022Article
- Transcriptome and QTL mapping analyses of major QTL genes controlling glucosinolate contents in vegetable- and oilseed-typeFrontiers in plant science · 2022Article
- Improvement of glucosinolates by metabolic engineering inaBIOTECH · 2021Review
- Article
- Comprehensive Transcriptomic Analysis for Developing Seeds of a SyntheticPlants (Basel, Switzerland) · 2020Article
- Dissection of genetic architecture for glucosinolate accumulations in leaves and seeds of Brassica napus by genome-wide association study.Plant biotechnology journal · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucosinolates (GSLs) are secondary metabolites that have anticarcinogenic activity and play defense roles in plants of the Brassicaceae family. MYB28 is known as a transcription factor that regulates aliphatic GSL biosynthesis in Arabidopsis thaliana. Brassicaceae plants have three orthologous copies of AtMYB28 derived from recent genome triplication. These BrMYB28 genes have a high level of sequence homology, with 81-87% similarities in the coding DNA sequence compared to Arabidopsis. Overexpression of three paralogous BrMYB28 genes in transgenic Chinese cabbage increased the total GSL content in all T1 generation plants and in two inbred lines of homozygous T2 plants. The highest total GSL contents were detected in homozygous T2 lines overexpressing BrMYB28.1, which showed an approximate fivefold increase compared to that of nontransgenic plants. The homozygous T2 lines with overexpressed BrMYB28.1 also showed an increased content of aliphatic, indolic, and aromatic GSLs compared to that of nontransgenic plants. Furthermore, all of the three BrMYB28 genes were identified as negative regulators of BrAOP2 and positive regulators of BrGSL-OH in the homozygous T2 lines. These data indicate the regulatory mechanism of GSL biosynthesis in B. rapa is unlike that in A. thaliana. Our results will provide useful information for elucidating the regulatory mechanism of GSL biosynthesis in polyploid plants.
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