ArticleGenetics in medicine : official journal of the American College of Medical Genetics2016
Adopting genetics: motivations and outcomes of personal genomic testing in adult adoptees.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Sharing behavior and health care utilization following direct-to-consumer genetic testing: a systematic review.Open research Europe · 2025Pooled it
- Outcomes from a Novel Approach to Studying Consumer Genetic Testing for Germline Cancer and Cardiovascular Risk.American journal of medical genetics. Part A · 2025Article
- Unmet Health Care Needs of Adult Patients Adopted in Childhood: Insights and Recommendations.Annals of family medicine · 2025Article
- Motivations, perceptions and impacts of direct-to-consumer genetic testing among users in Brazil.Journal of community genetics · 2025Article
- A Qualitative Study of Primary Care Physicians' Approaches to Caring for Adult Adopted Patients.Annals of family medicine · 2025Article
- Policy Guidance for Direct-to-Consumer Genetic Testing Services: Framework Development Study.Journal of medical Internet research · 2024Review
- Clinically Indicated Genomic Sequencing of Children in Foster Care: Legal and Ethical Issues.The Journal of pediatrics · 2023Article
- Adoptees' views and experiences of direct-to-consumer (DTC) genomic testing: an exploratory interview study from the UK.Journal of community genetics · 2023Article
- Considerations for developing regulations for direct-to-consumer genetic testing: a scoping review using the 3-I framework.Journal of community genetics · 2022Article
- Motivations and concerns of patients considering participation in an implementation study of a hereditary cancer risk assessment program in diverse primary care settings.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- A study of elective genome sequencing and pharmacogenetic testing in an unselected population.Molecular genetics & genomic medicine · 2021Article
- Third-Party Genetic Interpretation Tools: A Mixed-Methods Study of Consumer Motivation and Behavior.American journal of human genetics · 2019Article
- Autonomy, Well-Being, and the Value of Genetic Testing for Adopted Persons.HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues · 2018Article
- Implementation of personalized medicine in Central-Eastern Europe: pitfalls and potentials based on citizen's attitude.The EPMA journal · 2018Article
- Recent developments in genetics and medically assisted reproduction: from research to clinical applications.European journal of human genetics : EJHG · 2018Review
- Diet and exercise changes following direct-to-consumer personal genomic testing.BMC medical genomics · 2017Article
- Personal Genomic Testing for Cancer Risk: Results From the Impact of Personal Genomics Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Article
- Ancestry Testing and the Practice of Genetic Counseling.Journal of genetic counseling · 2017Review
- Recent developments in genetics and medically-assisted reproduction: from research to clinical applicationsHuman reproduction open · 2017Article
- Genomic sequencing in clinical practice: applications, challenges, and opportunities.Dialogues in clinical neuroscience · 2016Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeAmerican adult adoptees may possess limited information about their biological families and turn to direct-to-consumer personal genomic testing (PGT) for genealogical and medical information. We investigated the motivations and outcomes of adoptees undergoing PGT using data from the Impact of Personal Genomics (PGen) Study.
methodsThe PGen Study surveyed new 23andMe and Pathway Genomics customers before and 6 months after receiving PGT results. Exploratory analyses compared adoptees' and nonadoptees' PGT attitudes, expectations, and experiences. We evaluated the association of adoption status with motivations for testing and postdisclosure actions using logistic regression models.
resultsOf 1,607 participants, 80 (5%) were adopted. As compared with nonadoptees, adoptees were more likely to cite limited knowledge of family health history (OR = 10.1; 95% CI = 5.7-19.5) and the opportunity to learn genetic disease risks (OR = 2.7; 95% CI = 1.6-4.8) as strong motivations for PGT. Of 922 participants who completed 6-month follow-up, there was no significant association between adoption status and PGT-motivated health-care utilization or health-behavior change.
conclusionPGT allows adoptees to gain otherwise inaccessible information about their genetic disease risks and ancestry, helping them to fill the void of an incomplete family health history.Genet Med 18 9, 924-932.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.