Evidence map›Paper›PMID 26819956›Full record

ReviewJournal of immunology research2015

Immunoregulation of NKT Cells in Systemic Lupus Erythematosus.

Junwei Chen, Meng Wu, Jing Wang, Xiaofeng Li

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The role of IL-22 in cancer.Medical oncology (Northwood, London, England) · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury.International journal of molecular sciences · 2019
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Junwei ChenDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, China.
Meng WuDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, China.
Jing WangDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, China.
Xiaofeng LiDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, China.
Second Hospital of Shanxi Medical University · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with different variety of clinical manifestations. Natural killer T (NKT) cells are innate lymphocytes that play a regulatory role during broad range of immune responses. A number of studies demonstrated that the quantity and quality of invariant NKT (iNKT) cells showed marked defects in SLE patients in comparison to healthy controls. This finding suggests that iNKT cells may play a regulatory role in the occurrence and development of this disease. In this review, we mainly summarized the most recent findings about the behavior of NKT cells in SLE patients and mouse models, as well as how NKT cells affect the proportion of T helper cells and the production of autoreactive antibodies in the progress of SLE. This will help people better understand the role of NKT cells in the development of SLE and improve the therapy strategy.

Indexed as

AnimalsAutoantibodiesDisease Models, AnimalFemaleGene ExpressionHumansImmunosuppressive AgentsInterleukin-10Interleukin-17Lupus Erythematosus, SystemicMiceNatural Killer T-CellsSurvival AnalysisTh1 CellsTh1-Th2 BalanceTh2 CellsAutoantibodiesIL10 protein, humanImmunosuppressive AgentsInterleukin-10Interleukin-17Transforming Growth Factor beta

Identifiers

PMID26819956
PMCPMC4706917
OpenAlexW2267913201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.