ArticleBiomedical optics express2016
Label-free multi-photon imaging of dysplasia in Barrett's esophagus.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Fast multimodal imaging combined with machine learning identifying taurine as a potential marker for breast cancer margin assessment.NPJ digital medicine · 2025Article
- Label-free multimodal imaging with simultaneous two-photon and three-photon microscopy and kernel-based nonlinear scaling denoising.Biomedical optics express · 2024Article
- Characterization of lamina propria remodeling in pediatric eosinophilic esophagitis using second harmonic generation microscopy.Translational medicine communications · 2024Article
- Toward next-generation endoscopes integrating biomimetic video systems, nonlinear optical microscopy, and deep learning.Biophysics reviews · 2023Review
- Label-free highly multimodal nonlinear endoscope.Optics express · 2022Article
- Dual-wavelength multimodal multiphoton microscope with SMA-based depth scanning.Biomedical optics express · 2022Article
- Optical biopsy of laryngeal lesions using femtosecond multiphoton microscopy.Biomedical optics express · 2021Article
- Novel endoscopic optical diagnostic technologies in medical trial research: recent advancements and future prospects.Biomedical engineering online · 2021Review
- Second and third harmonic generation microscopy visualizes key structural components in fresh unprocessed healthy human breast tissue.Journal of biophotonics · 2019Article
- Compact fiber-based multi-photon endoscope working at 1700 nm.Biomedical optics express · 2018Article
- Imaging of targeted lipid microbubbles to detect cancer cells using third harmonic generation microscopy.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Barrett's esophagus (BE) is a metaplastic disorder where dysplastic and early cancerous changes are invisible to the naked eye and where the practice of blind biopsy is hampered by large sampling errors. Multi-photon microscopy (MPM) has emerged as an alternative solution for fast and label-free diagnostic capability for identifying the histological features with sub-micron accuracy. We developed a compact, inexpensive MPM system by using a handheld mode-locked fiber laser operating at 1560nm to study mucosal biopsies of BE. The combination of back-scattered THG, back-reflected forward THG and SHG signals generate images of cell nuclei and collagen, leading to label-free diagnosis in Barrett's.
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Registered trials
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