ArticleBiomedical optics express2016
Surface-modified complex SU-8 microstructures for indirect optical manipulation of single cells.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Light-driven soft microrobots based on hydrogels and LCEs: development and prospects.RSC advances · 2024Review
- MEMSbased Double-Stacked Tower Biosensor Array with Integrated Readout Circuitry for Detection of Salivary pH as a Diagnostic Biomarker Applied for Chronic Periodontal Disease.Sensors (Basel, Switzerland) · 2022Article
- Fabrication of Functional Microdevices in SU-8 by Multi-Photon Lithography.Micromachines · 2021Review
- Single-Cell Elasticity Measurement with an Optically Actuated Microrobot.Micromachines · 2020Article
- Optical Micromachines for Biological Studies.Micromachines · 2020Review
- Multiview microscopy of single cells through microstructure-based indirect optical manipulation.Biomedical optics express · 2020Article
- Rapid Fabrication of Continuous Surface Fresnel Microlens Array by Femtosecond Laser Focal Field Engineering.Micromachines · 2020Article
- Micromanipulation System for Isolating a SingleMicromachines · 2019Article
- Tele-Robotic Platform for Dexterous Optical Single-Cell Manipulation.Micromachines · 2019Article
- Imaging the cell.Biophysical reviews · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We introduce a method that combines two-photon polymerization (TPP) and surface functionalization to enable the indirect optical manipulation of live cells. TPP-made 3D microstructures were coated specifically with a multilayer of the protein streptavidin and non-specifically with IgG antibody using polyethylene glycol diamine as a linker molecule. Protein density on their surfaces was quantified for various coating methods. The streptavidin-coated structures were shown to attach to biotinated cells reproducibly. We performed basic indirect optical micromanipulation tasks with attached structure-cell couples using complex structures and a multi-focus optical trap. The use of such extended manipulators for indirect optical trapping ensures to keep a safe distance between the trapping beams and the sensitive cell and enables their 6 degrees of freedom actuation.
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Registered trials
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