ArticleNeural plasticity2016
Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury.
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional Connectivity Changes on Resting-State fMRI after Mild Traumatic Brain Injury: A Systematic Review.AJNR. American journal of neuroradiology · 2024Pooled it
- Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury.Neural plasticity · 2021Trial
- Analysis of Free-Living Mobility in People with Mild Traumatic Brain Injury and Healthy Controls: Quality over Quantity.Journal of neurotrauma · 2020Trial
- Harnessing machine learning for functional connectivity-based feature discovery in post-traumatic epilepsy.Neuroimage. Reports · 2026Article
- Impact frequency and interval modulate brain network outcomes in a rat model of repetitive mild traumatic brain injury.Scientific reports · 2026Article
- Reduced MOV10 reveals novel functional cortical connections in an increased fear response.bioRxiv : the preprint server for biology · 2026Article
- Relationship between spontaneous EEG oscillations at 7 and 45 days of acute plateau exposure and the plateau acclimatization index.Frontiers in neuroscience · 2026Article
- Group-wise sparse coding for the discovery of functional connectivity-based biomarkers in children and adolescents with autism spectrum disorder.Frontiers in psychiatry · 2026Article
- Cortical functional and structural alterations in rhegmatogenous retinal detachment: a multimodal analysis using surface-based independent component analysis, morphometry, and machine learning.Quantitative imaging in medicine and surgery · 2025Article
- Altered Effective Connectivity of the Numerical Brain in Children With Developmental Dyscalculia.Journal of neuroscience research · 2025Article
- High-magnitude headers are not associated with structural and functional brain changes in active high-level football (soccer) players.BMJ open sport & exercise medicine · 2025Article
- A Graph-Based Statistical Approach to Identifying Functional Connectivity Networks in Patients with Traumatic Brain Injury.Iranian journal of child neurology · 2025Article
- Graph Analysis of the Visual Cortical Network during Naturalistic Movie Viewing Reveals Increased Integration and Decreased Segregation Following Mild TBI.Vision (Basel, Switzerland) · 2024Article
- Disrupted topological organization of functional brain networks in traumatic axonal injury.Brain imaging and behavior · 2024Article
- Soccer heading immediately alters brain function and brain-muscle communication.Frontiers in human neuroscience · 2023Article
- Assessing blood oxygen level-dependent signal variability as a biomarker of brain injury in sport-related concussion.Brain communications · 2023Article
- Cognitive control subprocess deficits and compensatory modulation mechanisms in patients with frontal lobe injury revealed by EEG markers: a basic study to guide brain stimulation.General psychiatry · 2023Article
- Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse.Neurobiology of disease · 2023Article
- Editorial: Non-invasive brain stimulation techniques in neurological and neuropsychiatric disorders: Physiological and molecular evidence.Frontiers in systems neuroscience · 2023Article
- Therapeutic Neuromodulation toward a Critical State May Serve as a General Treatment Strategy.Biomedicines · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild traumatic brain injury (mTBI) is a major public health concern. Functional MRI has reported alterations in several brain networks following mTBI. However, the connectome-scale brain network changes are still unknown. In this study, sixteen mTBI patients were prospectively recruited from an emergency department and followed up at 4-6 weeks after injury. Twenty-four healthy controls were also scanned twice with the same time interval. Three hundred fifty-eight brain landmarks that preserve structural and functional correspondence of brain networks across individuals were used to investigate longitudinal brain connectivity. Network-based statistic (NBS) analysis did not find significant difference in the group-by-time interaction and time effects. However, 258 functional pairs show group differences in which mTBI patients have higher functional connectivity. Meta-analysis showed that "Action" and "Cognition" are the most affected functional domains. Categorization of connectomic signatures using multiview group-wise cluster analysis identified two patterns of functional hyperconnectivity among mTBI patients: (I) between the posterior cingulate cortex and the association areas of the brain and (II) between the occipital and the frontal lobes of the brain. Our results demonstrate that brain concussion renders connectome-scale brain network connectivity changes, and the brain tends to be hyperactivated to compensate the pathophysiological disturbances.
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