ArticleJournal of pharmaceutical health care and sciences2015
Switching from allopurinol to febuxostat: efficacy and tolerability in hemodialysis patients.
Article in Journal of pharmaceutical health care and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Urate lowering therapy in patients starting hemodialysis limit gout flares occurrence: ten years retrospective study.BMC nephrology · 2024Article
- Linagliptin possibly enhances the efficacy of allosteric xanthine oxidase inhibitors.International urology and nephrology · 2024Article
- Efficacy of febuxostat versus allopurinol and the predictors of achieving target serum urate in a cohort of Thai people with gout.Clinical rheumatology · 2021Article
- The efficacy and tolerability of febuxostat treatment in a cohort of Chinese Han population with history of gout.The Journal of international medical research · 2020Article
- The Effect of Xanthine Oxidase Inhibitors on Blood Pressure and Renal Function.Current hypertension reports · 2017Review
- Management of Gout and Hyperuricemia in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
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4 authors.
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Abstract
backgroundFebuxostat is a novel xanthine oxidase inhibitor. However, few studies have examined the long-term efficacy and tolerability of febuxostat after switching from allopurinol in hemodialysis (HD) patients. Therefore, the present study evaluated the long-term efficacy and tolerability of febuxostat in HD patients after switching from allopurinol.
findingsWe monitored the levels of hemoglobin, hematocrit, platelet count, blood urea nitrogen, serum creatinine, serum sodium, serum potassium, serum chloride, serum calcium, serum inorganic phosphorus, aspartate transaminase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, and total protein that were considered overall as a tolerability index, while the serum uric acid (UA) level was considered an index of efficacy. All values were measured at baseline and at 1, 6, 12, and 16 months after the switch to febuxostat therapy. All subjects switched from allopurinol (100 mg/day) to febuxostat (10 mg/day) in August 2013. Clinical laboratory data were collected at baseline in July 2013 until December 2014. Nine patients were included in the study analysis. Results showed that clinical laboratory data at baseline versus those at 16 months were not significantly different. Serum UA levels, which represented the efficacy index, were significantly different between the baseline level (6.8 ± 1.4) and those at 1, 6, 12, and 16 months (5.2 ± 1.1, 5.1 ± 1.1, 4.6 ± 0.9, and 5.4 ± 1.8 mg/dL, respectively; all p < 0.05).
conclusionSwitching from allopurinol to febuxostat in HD patients reduced serum UA levels, with no changes in other clinical laboratory data in the long term.
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