ArticleJournal of cancer science & therapy
Comparative Analysis of Differentially Expressed miRNAs and their Downstream mRNAs in Ovarian Cancer and its Associated Endometriosis.
Article in Journal of cancer science & therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- MicroRNA Expression Profile in Endometriosis and Endometriosis-Associated Ovarian Cancer-Systematic Review.Cells · 2026Review
- PTEN-mediated resistance in cancer: From foundation to future therapies.Toxicology reports · 2025Review
- Reassessing the Role of Tissue Factor Pathway Inhibitor 2 in Neoplastic and Non-Neoplastic Lesions.Cancers · 2025Review
- Identification of Key miRNAs in Endometriosis.MicroRNA (Shariqah, United Arab Emirates) · 2025Article
- Exploring the Role of MicroRNAs in Progesterone and Estrogen Receptor Expression in Endometriosis.Biomedicines · 2024Article
- Influence of Clinical Factors on miR-3613-3p Expression in Colorectal Cancer.International journal of molecular sciences · 2023Article
- Malignant transformation of endometriosis in a laparoscopic trocar site a case report.BMC women's health · 2022Article
- miR 31-3p Has the Highest Expression in Cesarean Scar Endometriosis.International journal of molecular sciences · 2022Article
- Article
- Reference Genes for qPCR-Based miRNA Expression Profiling in 14 Human Tissues.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022Review
- miR-335 Restrains the Aggressive Phenotypes of Ovarian Cancer Cells by Inhibiting COL11A1.Cancers · 2021Article
- Endometriosis and gynaecological cancers: molecular insights behind a complex machinery.Przeglad menopauzalny = Menopause review · 2021Review
- Endometriosis and ovarian cancer risk, an epigenetic connection.Annals of translational medicine · 2020Review
- The differential expression of miRNAs between ovarian endometrioma and endometriosis-associated ovarian cancer.Journal of ovarian research · 2020Article
- Endometriosis and risk of ovarian cancer: what do we know?Archives of gynecology and obstetrics · 2020Review
- MicroRNAs play an important role in contributing to arsenic susceptibility in the chronically exposed individuals of West Bengal, India.Environmental science and pollution research international · 2019Article
- Reduced microRNA-451 expression in eutopic endometrium contributes to the pathogenesis of endometriosis.World journal of clinical cases · 2019Article
- Epithelial-mesenchymal transition markers screened in a cell-based model and validated in lung adenocarcinoma.BMC cancer · 2019Article
- MicroRNAs in endometriosis: biological function and emerging biomarker candidates†.Biology of reproduction · 2019Review
- High-Grade Serous Carcinoma Resulting From Rectal Endometriosis and Complicated With Ovarian Cancer.Frontiers in oncology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThere is an increased risk of developing ovarian cancer (OC) in patients with endometriosis. Hence, development of new biomarkers may provide a positive clinical outcome for early detection. MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in biological and pathological process and are currently used as diagnostic and prognostic markers in various cancers. In the current study, we assessed the differential expression of miRNAs from 19 paired ovarian cancer and its associated endometriosis tissue samples. In addition we also analyzed the downstream targets of those miRNAs.
methodsNineteen paired cases of ovarian cancer and endometriosis foci were identified by a gynecologic pathologist and macro-dissected. The total RNAs were extracted and subjected to comprehensive miRNA profiling from the pooled samples of these two different entities using microarray analysis. Later, the abnormal expressions of few selected miRNAs were validated in individual cases by quantitative real-time PCR (qRT-PCR). Ingenuity pathway analysis revealed target mRNAs which were validated by qRT-PCR.
resultsThe miRNA profiling identified deregulation of greater than 1156 miRNAs in OC, of which the top seven were further validated by qRT-PCR. The expression of
conclusionThe expression of miRNAs and mRNAs in OC were significantly different compared to its concurrent endometriosis. These differential expressed miRNAs may serve as potential diagnostic and prognostic biomarkers for OC associated with endometriosis.
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