Evidence map›Paper›PMID 26819661›Full record

ArticleACS medicinal chemistry letters2016

Role of a Preorganized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Progression.

Barbara Richichi, Giuseppina Comito, Olivier Renaudet, Michele Fiore, A Marra, B Stecca, L Pasquato, P Chiarugi, C Nativi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Barbara RichichiDepartment of Chemistry "Ugo Schiff″, University of Florence , via della Lastruccia, 13 50019 Sesto F.no (FI), Italy.
Giuseppina ComitoDepartment of Experimental and Clinical Biomedical Sciences, Biochemistry, Human Health Medical School, University of Florence , viale Morgagni 50, 50134 Firenze, Italy.
Olivier RenaudetUniversité Grenoble-Alpes, and CNRS, DCM, 38000 Grenoble, France; Institut Universitaire de France, 103 Boulevard Saint-Michel, 75005 Paris, France.
Michele FioreUniversité Grenoble-Alpes, and CNRS, DCM , 38000 Grenoble, France.
A MarraInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247, Ecole Nationale Supérieure de Chimie de Montpellier , 8 Rue de l'Ecole Normale, 34296 Montpellier cedex 5, France.
B SteccaCore Research Laboratory, Istituto Toscano Tumori , viale Pieraccini, 6, 50139 Firenze, Italy.
L PasquatoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste , via L. Giorgieri 1, 34127 Trieste, Italy.
P ChiarugiDepartment of Experimental and Clinical Biomedical Sciences, Biochemistry, Human Health Medical School, University of Florence , viale Morgagni 50, 50134 Firenze, Italy.
C NativiDepartment of Chemistry "Ugo Schiff″, University of Florence, via della Lastruccia, 13 50019 Sesto F.no (FI), Italy; FiorGen, Polo Scientifico e Tecnologico, via Sacconi, 6 50019 Sesto F.no (FI), Italy.
University of Florence · ITCentre National de la Recherche Scientifique · FRÉcole Nationale Supérieure de Chimie de Montpellier · FRPolo d’Innovazione di Genomica · ITTumour Institute of Tuscany · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two tetravalent architectures, the glycocalix 7 and the RAFT 9, presenting four residues of a GM-3 ganglioside lactone mimetic, target the host compartment of melanoma and significantly abrogate the effect induced by cancer-associated fibroblasts (CAFs) contact + hypoxia in the motility and invasiveness of tumor cells. The data reported support the involvement of glycosphingolipids (GSLs) in hypoxia and show an interesting role played by compound 9 in targeting melanoma cells thereby interfering with melanoma progression. The unprecedented findings reported for the glycocluster 9 may contribute to the understanding of the critical and complex interactions between tumor cells and their local environment paving the way for new therapeutic agents.

Indexed as

Glycosidesmimeticstumor antigentumor microenvironment

Identifiers

PMID26819661
PMCPMC4716596
OpenAlexW2343032189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.