ArticleThyroid research2016
Association between iron status and thyroid function in Nepalese children.
Article in Thyroid research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Nutritional Status of Iodine and Association with Iron, Selenium, and Zinc in Population Studies: A Systematic Review and Meta-Analysis.Nutrients · 2025Pooled it
- The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data.The Journal of clinical endocrinology and metabolism · 2018Pooled it
- Review
- The Role of Immunological Challenges, Oxidative Stress, and Dietary Interventions in Managing Hashimoto's Thyroiditis: A Narrative Review.Nutrition reviews · 2026Review
- Diabetes, Iron-Deficiency Anemia, and Endocrine, Nutritional, and Metabolic Disorders in Children: A Socio-Epidemiological Study in Urban Kazakhstan.International journal of environmental research and public health · 2025Article
- Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis.International journal of endocrinology and metabolism · 2024Article
- Association between small intestine bacterial overgrowth and psychiatric disorders.Frontiers in endocrinology · 2024Review
- Review
- The interplay of oxidative stress and immune dysfunction in Hashimoto's thyroiditis and polycystic ovary syndrome: a comprehensive review.Frontiers in immunology · 2023Review
- Thyroidal and Extrathyroidal Requirements for Iodine and Selenium: A Combined Evolutionary and (Patho)Physiological Approach.Nutrients · 2022Review
- Selected Essential and Toxic Chemical Elements in Hypothyroidism-A Literature Review (2001-2021).International journal of molecular sciences · 2021Review
- Mild Anemia May Affect Thyroid Function in Pregnant Chinese Women During the First Trimester.Frontiers in endocrinology · 2021Article
- Article
- Review
- Bidirectional Interaction of Thyroid-Kidney Organs in Disease States.International journal of nephrology · 2020Article
- Association of exposure to multiple metals with papillary thyroid cancer risk in China.Environmental science and pollution research international · 2019Article
- Association of antithyroglobulin antibody with iodine nutrition and thyroid dysfunction in Nepalese children.Thyroid research · 2019Article
- Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects.Mediators of inflammation · 2019Article
- Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study.Scientific reports · 2018Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between iron status and thyroid function in Nepalese children living in hilly regions.
methodsA cross-sectional study was conducted among 227 school children aged 6-12 years living in hilly regions of eastern Nepal. Urine and blood samples were analyzed for urinary iodine concentration, free thyroxine, free triiodothyronine, thyroid stimulating hormone, hemoglobin, serum iron and total iron binding capacity, and percentage transferrin saturation was calculated.
resultsThe cohort comprised euthyroid (80.6 %, n = 183), overt hypothyroid (1.3 %, n = 3), subclinical hypothyroid (16.3 %, n = 37) and subclinical hyperthyroid (1.8 %, n = 4) children respectively. About 35.2 % (n = 80) children were anemic, 43.6 % (n = 99) were iron deficient and 19.8 % (n = 45) had urinary iodine excretion < 100 μg/L. Hypothyroidism (overt and subclinical) was common in anemic and iron deficient children. The relative risk of having hypothyroidism (overt and subclinical) in anemic and iron deficient children was 5.513 (95 % CI: 2.844-10.685, p < 0.001) and 1.939 (95 % CI: 1.091-3.449, p = 0.023) respectively as compared to non-anemic and iron sufficient children. Thyroid stimulating hormone had significant negative correlation with hemoglobin (r = -0.337, p < 0.001) and transferrin saturation (r = -0.204, p = 0.002).
conclusionsThyroid dysfunction, iron deficiency and anemia are common among Nepalese children. In this cohort, anemic and iron deficient children had poor thyroid function.
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Registered trials
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